Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration

BACKGROUND: Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) share phenotypic and molecular commonalities, including the fact that they can be caused by mutations in ubiquitous proteins involved in RNA metabolism, namely SMN, TDP-43 and FUS. Although this suggests the existence...

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Detalles Bibliográficos
Autores principales: Garcia-Vaquero, Marina L., Heim, Marjorie, Flix, Barbara, Pereira, Marcelo, Palin, Lucile, Marques, Tânia M., Pinto, Francisco R., de Las Rivas, Javier, Voigt, Aaron, Besse, Florence, Gama-Carvalho, Margarida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523761/
https://www.ncbi.nlm.nih.gov/pubmed/37759179
http://dx.doi.org/10.1186/s12864-023-09562-4

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