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Serial head circumference measurements should be used to classify congenital microcephaly
BACKGROUND: Measuring the maximum occipitofrontal circumference only once at birth or within 24 h after birth may lead to misclassifications of microcephaly. This study compared the head circumference (HC) of newborns at birth or within 24 h after birth to their third day of life (DOL3) as well as e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523790/ https://www.ncbi.nlm.nih.gov/pubmed/37759153 http://dx.doi.org/10.1186/s12887-023-04315-4 |
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author | Sengasai, Chutima Chokephaibulkit, Kulkanya Plipat, Nottasorn Wongsiridej, Pimol |
author_facet | Sengasai, Chutima Chokephaibulkit, Kulkanya Plipat, Nottasorn Wongsiridej, Pimol |
author_sort | Sengasai, Chutima |
collection | PubMed |
description | BACKGROUND: Measuring the maximum occipitofrontal circumference only once at birth or within 24 h after birth may lead to misclassifications of microcephaly. This study compared the head circumference (HC) of newborns at birth or within 24 h after birth to their third day of life (DOL3) as well as evaluated maternal- and infant-specific factors associated with increased HC by DOL3. METHODS: This prospective study included 1131 live births between February and May 2019 with a gestational age > 27 weeks. All newborns had their HC measured at birth or within 24 h after birth as well as on DOL3 before discharge. HC measurements were performed by trained personnel using non-elastic tape measures. The World Health Organization (WHO) and Fenton Growth Charts were used as reference ranges for interpretation of full-term and preterm neonates, respectively. RESULTS: Paired sample t-test analyses found a statistically significant increase in HC measured on the DOL3 compared with HCs of the same newborns at birth or within 24 h of birth. The mean HC increase was 0.17 cm (95% confidence interval [0.13, 0.21], P < 0.001). The mean ± standard deviation HC within 24 h of birth and at DOL3 were 33.58 ± 1.53 cm and 33.75 ± 1.37 cm, respectively. Thirty-two newborns had HCs less than the third percentile (< P3) at birth, 25 of which had HC ≥ P3 at DOL3. After adjusting for mode of and presentation at delivery, newborns whose mothers experienced labor pains (β = 0.31, P < 0.001) and were either symmetrically (β = 0.59, P = 0.002) or asymmetrically small-for-gestational age (SGA; β = 0.37, P = 0.03) had significantly increased HC at DOL3. On average, newborns whose mothers experienced labor pain had 0.31 cm increases in HC at DOL3. Symmetrical SGA newborns also had an average 0.59 cm increase in HC at DOL3. Parity and gestational age were not associated with changes in HC. CONCLUSIONS: Serial HC measurements on DOL3 or before newborns’ discharge is crucial to classifying congenital microcephaly. |
format | Online Article Text |
id | pubmed-10523790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105237902023-09-28 Serial head circumference measurements should be used to classify congenital microcephaly Sengasai, Chutima Chokephaibulkit, Kulkanya Plipat, Nottasorn Wongsiridej, Pimol BMC Pediatr Research Article BACKGROUND: Measuring the maximum occipitofrontal circumference only once at birth or within 24 h after birth may lead to misclassifications of microcephaly. This study compared the head circumference (HC) of newborns at birth or within 24 h after birth to their third day of life (DOL3) as well as evaluated maternal- and infant-specific factors associated with increased HC by DOL3. METHODS: This prospective study included 1131 live births between February and May 2019 with a gestational age > 27 weeks. All newborns had their HC measured at birth or within 24 h after birth as well as on DOL3 before discharge. HC measurements were performed by trained personnel using non-elastic tape measures. The World Health Organization (WHO) and Fenton Growth Charts were used as reference ranges for interpretation of full-term and preterm neonates, respectively. RESULTS: Paired sample t-test analyses found a statistically significant increase in HC measured on the DOL3 compared with HCs of the same newborns at birth or within 24 h of birth. The mean HC increase was 0.17 cm (95% confidence interval [0.13, 0.21], P < 0.001). The mean ± standard deviation HC within 24 h of birth and at DOL3 were 33.58 ± 1.53 cm and 33.75 ± 1.37 cm, respectively. Thirty-two newborns had HCs less than the third percentile (< P3) at birth, 25 of which had HC ≥ P3 at DOL3. After adjusting for mode of and presentation at delivery, newborns whose mothers experienced labor pains (β = 0.31, P < 0.001) and were either symmetrically (β = 0.59, P = 0.002) or asymmetrically small-for-gestational age (SGA; β = 0.37, P = 0.03) had significantly increased HC at DOL3. On average, newborns whose mothers experienced labor pain had 0.31 cm increases in HC at DOL3. Symmetrical SGA newborns also had an average 0.59 cm increase in HC at DOL3. Parity and gestational age were not associated with changes in HC. CONCLUSIONS: Serial HC measurements on DOL3 or before newborns’ discharge is crucial to classifying congenital microcephaly. BioMed Central 2023-09-27 /pmc/articles/PMC10523790/ /pubmed/37759153 http://dx.doi.org/10.1186/s12887-023-04315-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Sengasai, Chutima Chokephaibulkit, Kulkanya Plipat, Nottasorn Wongsiridej, Pimol Serial head circumference measurements should be used to classify congenital microcephaly |
title | Serial head circumference measurements should be used to classify congenital microcephaly |
title_full | Serial head circumference measurements should be used to classify congenital microcephaly |
title_fullStr | Serial head circumference measurements should be used to classify congenital microcephaly |
title_full_unstemmed | Serial head circumference measurements should be used to classify congenital microcephaly |
title_short | Serial head circumference measurements should be used to classify congenital microcephaly |
title_sort | serial head circumference measurements should be used to classify congenital microcephaly |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523790/ https://www.ncbi.nlm.nih.gov/pubmed/37759153 http://dx.doi.org/10.1186/s12887-023-04315-4 |
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