Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties

BACKGROUND: Super-enhancers (SEs), which activate genes involved in cell-type specificity, have mainly been defined as genomic regions with top-ranked enrichment(s) of histone H3 with acetylated K27 (H3K27ac) and/or transcription coactivator(s) including a bromodomain and extra-terminal domain (BET)...

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Detalles Bibliográficos
Autores principales: Das, Nando D., Chang, Jen-Chien, Hon, Chung-Chau, Kelly, S. Thomas, Ito, Shinsuke, Lizio, Marina, Kaczkowski, Bogumil, Watanabe, Hisami, Katsushima, Keisuke, Natsume, Atsushi, Koseki, Haruhiko, Kondo, Yutaka, Minoda, Aki, Umehara, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523799/
https://www.ncbi.nlm.nih.gov/pubmed/37759202
http://dx.doi.org/10.1186/s12864-023-09659-w

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