Chemogenetic Silencing of Na(V)1.8-Positive Sensory Neurons Reverses Chronic Neuropathic and Bone Cancer Pain in FLEx PSAM(4)-GlyR Mice

Drive from peripheral neurons is essential in almost all pain states, but pharmacological silencing of these neurons to effect analgesia has proved problematic. Reversible gene therapy using long-lived chemogenetic approaches is an appealing option. We used the genetically activated chloride channel...

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Detalles Bibliográficos
Autores principales: Haroun, Rayan, Gossage, Samuel J., Luiz, Ana Paula, Arcangeletti, Manuel, Sikandar, Shafaq, Zhao, Jing, Cox, James J., Wood, John N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523839/
https://www.ncbi.nlm.nih.gov/pubmed/37679042
http://dx.doi.org/10.1523/ENEURO.0151-23.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523839/
https://www.ncbi.nlm.nih.gov/pubmed/37679042
http://dx.doi.org/10.1523/ENEURO.0151-23.2023

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