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The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study

OBJECTIVES: The aim of this study was to compare the metastatic patterns of synchronous bone metastasis (SBM) and metachronous bone metastasis (MBM) in nasopharyngeal carcinoma (NPC). METHODS: This study included bone metastases in NPC patients from 2005 to 2016 in a Chinese hospital. Cohort 1 was c...

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Autores principales: Luo, Dong‐Hua, Li, Jia‐Xin, Guo, Wan‐Ping, Guo, Chen‐Guang, Meng, Xiao‐Han, Xie, Pei‐Jun, Lin, Jie‐Yi, Mo, Hao‐Yuan, Zhang, Qun, Chen, Yong, Shen, Guo‐Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523956/
https://www.ncbi.nlm.nih.gov/pubmed/37563937
http://dx.doi.org/10.1002/cam4.6383
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author Luo, Dong‐Hua
Li, Jia‐Xin
Guo, Wan‐Ping
Guo, Chen‐Guang
Meng, Xiao‐Han
Xie, Pei‐Jun
Lin, Jie‐Yi
Mo, Hao‐Yuan
Zhang, Qun
Chen, Yong
Shen, Guo‐Ping
author_facet Luo, Dong‐Hua
Li, Jia‐Xin
Guo, Wan‐Ping
Guo, Chen‐Guang
Meng, Xiao‐Han
Xie, Pei‐Jun
Lin, Jie‐Yi
Mo, Hao‐Yuan
Zhang, Qun
Chen, Yong
Shen, Guo‐Ping
author_sort Luo, Dong‐Hua
collection PubMed
description OBJECTIVES: The aim of this study was to compare the metastatic patterns of synchronous bone metastasis (SBM) and metachronous bone metastasis (MBM) in nasopharyngeal carcinoma (NPC). METHODS: This study included bone metastases in NPC patients from 2005 to 2016 in a Chinese hospital. Cohort 1 was collected from 2005 to 2010 for discovery, and Cohort 2 from 2011 to 2016 for validation. The chi‐squared test, Wilcoxon rank sum test, and Kaplan–Meier technique were used to compare site, time, and survival between cohorts 1 and 2. Prognostic factors were analyzed using univariate or multivariate Cox regression. RESULTS: Cohort 1 had 112 individuals with SBM and 394 with MBM, and cohort 2 had 328 with SBM and 307 with MBM. The thoracic vertebra was the most frequently affected site of metastasis. Patients with SBM more often had metastasis to the cervical vertebrae compared with patients with MBM (34.5% vs. 22.3%, p < 0.05). Patients with SBM had better overall survival (42.2 months, 95% CI: 33.9–50.7) than patients with MBM (24.9 months, 95% CI: 22.2–28.7). Age at bone metastasis detection, metastasis to other organs, and more bone metastasis locations were associated with worse prognosis. The majority of MBMs occurred at 7 to 18 months after NPC diagnosis. CONCLUSION: Radiotherapy does not modify the metastatic patterns of NPC bone metastases. Patients with SBM tend to have metastasis to the cervical vertebra, which is close to the nasopharynx. Paying more attention to bone metastases during follow‐up in the first 2 years after an NPC diagnosis.
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spelling pubmed-105239562023-09-28 The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study Luo, Dong‐Hua Li, Jia‐Xin Guo, Wan‐Ping Guo, Chen‐Guang Meng, Xiao‐Han Xie, Pei‐Jun Lin, Jie‐Yi Mo, Hao‐Yuan Zhang, Qun Chen, Yong Shen, Guo‐Ping Cancer Med RESEARCH ARTICLES OBJECTIVES: The aim of this study was to compare the metastatic patterns of synchronous bone metastasis (SBM) and metachronous bone metastasis (MBM) in nasopharyngeal carcinoma (NPC). METHODS: This study included bone metastases in NPC patients from 2005 to 2016 in a Chinese hospital. Cohort 1 was collected from 2005 to 2010 for discovery, and Cohort 2 from 2011 to 2016 for validation. The chi‐squared test, Wilcoxon rank sum test, and Kaplan–Meier technique were used to compare site, time, and survival between cohorts 1 and 2. Prognostic factors were analyzed using univariate or multivariate Cox regression. RESULTS: Cohort 1 had 112 individuals with SBM and 394 with MBM, and cohort 2 had 328 with SBM and 307 with MBM. The thoracic vertebra was the most frequently affected site of metastasis. Patients with SBM more often had metastasis to the cervical vertebrae compared with patients with MBM (34.5% vs. 22.3%, p < 0.05). Patients with SBM had better overall survival (42.2 months, 95% CI: 33.9–50.7) than patients with MBM (24.9 months, 95% CI: 22.2–28.7). Age at bone metastasis detection, metastasis to other organs, and more bone metastasis locations were associated with worse prognosis. The majority of MBMs occurred at 7 to 18 months after NPC diagnosis. CONCLUSION: Radiotherapy does not modify the metastatic patterns of NPC bone metastases. Patients with SBM tend to have metastasis to the cervical vertebra, which is close to the nasopharynx. Paying more attention to bone metastases during follow‐up in the first 2 years after an NPC diagnosis. John Wiley and Sons Inc. 2023-08-10 /pmc/articles/PMC10523956/ /pubmed/37563937 http://dx.doi.org/10.1002/cam4.6383 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Luo, Dong‐Hua
Li, Jia‐Xin
Guo, Wan‐Ping
Guo, Chen‐Guang
Meng, Xiao‐Han
Xie, Pei‐Jun
Lin, Jie‐Yi
Mo, Hao‐Yuan
Zhang, Qun
Chen, Yong
Shen, Guo‐Ping
The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study
title The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study
title_full The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study
title_fullStr The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study
title_full_unstemmed The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study
title_short The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study
title_sort map of bone metastasis in nasopharyngeal carcinoma: a real‐world study
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523956/
https://www.ncbi.nlm.nih.gov/pubmed/37563937
http://dx.doi.org/10.1002/cam4.6383
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