The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration. We generated a novel monoclonal antibody agains...

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Detalles Bibliográficos
Autores principales: Chaudhri, Apoorvi, Bu, Xia, Wang, Yunfei, Gomez, Michael, Torchia, James A., Hua, Ping, Hung, Shao-Hsi, Davies, Michael A., Lizee, Gregory A., von Andrian, Ulrich, Hwu, Patrick, Freeman, Gordon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524267/
https://www.ncbi.nlm.nih.gov/pubmed/37771579
http://dx.doi.org/10.3389/fimmu.2023.1237715

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