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The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies

SIMPLE SUMMARY: In this review article, we present the fascinating story of sirolimus (rapamycin), a drug known to be able to induce fetal hemoglobin, and for this reason of great interest for the treatment of β-thalassemia. In fact, high levels of fetal hemoglobin have been demonstrated to be benef...

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Detalles Bibliográficos
Autores principales:	Gambari, Roberto, Zuccato, Cristina, Cosenza, Lucia Carmela, Zurlo, Matteo, Gasparello, Jessica, Finotti, Alessia, Gamberini, Maria Rita, Prosdocimi, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525103/ https://www.ncbi.nlm.nih.gov/pubmed/37759601 http://dx.doi.org/10.3390/biology12091202

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