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The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics

Superoxide dismutase (SOD) is a class of enzymes that restrict the biological oxidant cluster enzyme system in the body, which can effectively respond to cellular oxidative stress, lipid metabolism, inflammation, and oxidation. Published studies have shown that SOD enzymes (SODs) could maintain a dy...

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Detalles Bibliográficos
Autores principales: Zheng, Mengli, Liu, Yating, Zhang, Guanfeng, Yang, Zhikang, Xu, Weiwei, Chen, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525108/
https://www.ncbi.nlm.nih.gov/pubmed/37759978
http://dx.doi.org/10.3390/antiox12091675
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author Zheng, Mengli
Liu, Yating
Zhang, Guanfeng
Yang, Zhikang
Xu, Weiwei
Chen, Qinghua
author_facet Zheng, Mengli
Liu, Yating
Zhang, Guanfeng
Yang, Zhikang
Xu, Weiwei
Chen, Qinghua
author_sort Zheng, Mengli
collection PubMed
description Superoxide dismutase (SOD) is a class of enzymes that restrict the biological oxidant cluster enzyme system in the body, which can effectively respond to cellular oxidative stress, lipid metabolism, inflammation, and oxidation. Published studies have shown that SOD enzymes (SODs) could maintain a dynamic balance between the production and scavenging of biological oxidants in the body and prevent the toxic effects of free radicals, and have been shown to be effective in anti-tumor, anti-radiation, and anti-aging studies. This research summarizes the types, biological functions, and regulatory mechanisms of SODs, as well as their applications in medicine, food production, and cosmetic production. SODs have proven to be a useful tool in fighting disease, and mimetics and conjugates that report SODs have been developed successively to improve the effectiveness of SODs. There are still obstacles to solving the membrane permeability of SODs and the persistence of enzyme action, which is still a hot spot and difficulty in mining the effect of SODs and promoting their application in the future.
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spelling pubmed-105251082023-09-28 The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics Zheng, Mengli Liu, Yating Zhang, Guanfeng Yang, Zhikang Xu, Weiwei Chen, Qinghua Antioxidants (Basel) Review Superoxide dismutase (SOD) is a class of enzymes that restrict the biological oxidant cluster enzyme system in the body, which can effectively respond to cellular oxidative stress, lipid metabolism, inflammation, and oxidation. Published studies have shown that SOD enzymes (SODs) could maintain a dynamic balance between the production and scavenging of biological oxidants in the body and prevent the toxic effects of free radicals, and have been shown to be effective in anti-tumor, anti-radiation, and anti-aging studies. This research summarizes the types, biological functions, and regulatory mechanisms of SODs, as well as their applications in medicine, food production, and cosmetic production. SODs have proven to be a useful tool in fighting disease, and mimetics and conjugates that report SODs have been developed successively to improve the effectiveness of SODs. There are still obstacles to solving the membrane permeability of SODs and the persistence of enzyme action, which is still a hot spot and difficulty in mining the effect of SODs and promoting their application in the future. MDPI 2023-08-27 /pmc/articles/PMC10525108/ /pubmed/37759978 http://dx.doi.org/10.3390/antiox12091675 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zheng, Mengli
Liu, Yating
Zhang, Guanfeng
Yang, Zhikang
Xu, Weiwei
Chen, Qinghua
The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics
title The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics
title_full The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics
title_fullStr The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics
title_full_unstemmed The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics
title_short The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics
title_sort applications and mechanisms of superoxide dismutase in medicine, food, and cosmetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525108/
https://www.ncbi.nlm.nih.gov/pubmed/37759978
http://dx.doi.org/10.3390/antiox12091675
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