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Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study

Background: Moderate renal artery stenosis (50–70%) may lead to uncontrolled hypertension and eventually cause irreversible damage to renal function. However, the clinical criteria for interventional treatment are still ambiguous in this condition. This study investigated the impact of the position...

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Autores principales: Zhao, Yawei, Shi, Yike, Jin, Yusheng, Cao, Yifan, Song, Hui, Chen, Lingfeng, Li, Fen, Li, Xiaona, Chen, Weiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525140/
https://www.ncbi.nlm.nih.gov/pubmed/37760104
http://dx.doi.org/10.3390/bioengineering10091002
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author Zhao, Yawei
Shi, Yike
Jin, Yusheng
Cao, Yifan
Song, Hui
Chen, Lingfeng
Li, Fen
Li, Xiaona
Chen, Weiyi
author_facet Zhao, Yawei
Shi, Yike
Jin, Yusheng
Cao, Yifan
Song, Hui
Chen, Lingfeng
Li, Fen
Li, Xiaona
Chen, Weiyi
author_sort Zhao, Yawei
collection PubMed
description Background: Moderate renal artery stenosis (50–70%) may lead to uncontrolled hypertension and eventually cause irreversible damage to renal function. However, the clinical criteria for interventional treatment are still ambiguous in this condition. This study investigated the impact of the position and degree of renal artery stenosis on hemodynamics near the renal artery to assess the short-term and long-term risks associated with this disease. Methods: Calculation models with different degrees of stenosis (50%, 60%, and 70%) located at different positions in the right renal artery were established based on the computed tomography angiography (CTA) of a personalized case. And computational fluid dynamics (CFD) was used to analyze hemodynamic surroundings near the renal artery. Results: As the degree of stenosis increases and the stenosis position is far away from the aorta, there is a decrease in renal perfusion. An analysis of the wall shear stress (WSS)-related parameters indicated areas near the renal artery (downstream of the stenosis and the entrance of the right renal artery) with potential long-term risks of thrombosis and inflammation. Conclusion: The position and degree of stenosis play a significant role in judging short-term risks associated with renal perfusion. Moreover, clinicians should consider not only short-term risks but also independent long-term risk factors, such as certain regions of 50% stenosis with adequate renal perfusion may necessitate prompt intervention.
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spelling pubmed-105251402023-09-28 Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study Zhao, Yawei Shi, Yike Jin, Yusheng Cao, Yifan Song, Hui Chen, Lingfeng Li, Fen Li, Xiaona Chen, Weiyi Bioengineering (Basel) Article Background: Moderate renal artery stenosis (50–70%) may lead to uncontrolled hypertension and eventually cause irreversible damage to renal function. However, the clinical criteria for interventional treatment are still ambiguous in this condition. This study investigated the impact of the position and degree of renal artery stenosis on hemodynamics near the renal artery to assess the short-term and long-term risks associated with this disease. Methods: Calculation models with different degrees of stenosis (50%, 60%, and 70%) located at different positions in the right renal artery were established based on the computed tomography angiography (CTA) of a personalized case. And computational fluid dynamics (CFD) was used to analyze hemodynamic surroundings near the renal artery. Results: As the degree of stenosis increases and the stenosis position is far away from the aorta, there is a decrease in renal perfusion. An analysis of the wall shear stress (WSS)-related parameters indicated areas near the renal artery (downstream of the stenosis and the entrance of the right renal artery) with potential long-term risks of thrombosis and inflammation. Conclusion: The position and degree of stenosis play a significant role in judging short-term risks associated with renal perfusion. Moreover, clinicians should consider not only short-term risks but also independent long-term risk factors, such as certain regions of 50% stenosis with adequate renal perfusion may necessitate prompt intervention. MDPI 2023-08-24 /pmc/articles/PMC10525140/ /pubmed/37760104 http://dx.doi.org/10.3390/bioengineering10091002 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Yawei
Shi, Yike
Jin, Yusheng
Cao, Yifan
Song, Hui
Chen, Lingfeng
Li, Fen
Li, Xiaona
Chen, Weiyi
Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study
title Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study
title_full Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study
title_fullStr Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study
title_full_unstemmed Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study
title_short Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity: A Hemodynamic Study
title_sort evaluating short-term and long-term risks associated with renal artery stenosis position and severity: a hemodynamic study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525140/
https://www.ncbi.nlm.nih.gov/pubmed/37760104
http://dx.doi.org/10.3390/bioengineering10091002
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