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Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites

Hypertension and derived cardiovascular disease (CVD) are among the leading causes of death worldwide. Increased oxidative stress and inflammatory state are involved in different alterations in endothelial functions that contribute to the onset of CVD. Polyphenols, and in particular anthocyanins, ha...

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Autores principales: Laudani, Samuele, Godos, Justyna, Di Domenico, Federica Martina, Barbagallo, Ignazio, Randazzo, Cinzia Lucia, Leggio, Gian Marco, Galvano, Fabio, Grosso, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525277/
https://www.ncbi.nlm.nih.gov/pubmed/37760077
http://dx.doi.org/10.3390/antiox12091773
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author Laudani, Samuele
Godos, Justyna
Di Domenico, Federica Martina
Barbagallo, Ignazio
Randazzo, Cinzia Lucia
Leggio, Gian Marco
Galvano, Fabio
Grosso, Giuseppe
author_facet Laudani, Samuele
Godos, Justyna
Di Domenico, Federica Martina
Barbagallo, Ignazio
Randazzo, Cinzia Lucia
Leggio, Gian Marco
Galvano, Fabio
Grosso, Giuseppe
author_sort Laudani, Samuele
collection PubMed
description Hypertension and derived cardiovascular disease (CVD) are among the leading causes of death worldwide. Increased oxidative stress and inflammatory state are involved in different alterations in endothelial functions that contribute to the onset of CVD. Polyphenols, and in particular anthocyanins, have aroused great interest for their antioxidant effects and their cardioprotective role. However, anthocyanins are rarely detected in blood serum because they are primarily metabolized by the gut microbiota. This review presents studies published to date that report the main results from clinical studies on the cardioprotective effects of anthocyanins and the role of the gut microbiota in the metabolism and bioavailability of anthocyanins and their influence on the composition of the microbiota. Even if it seems that anthocyanins have a significant effect on vascular health, more studies are required to better clarify which molecules and doses show vascular benefits without forgetting the crucial role of the microbiota.
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spelling pubmed-105252772023-09-28 Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites Laudani, Samuele Godos, Justyna Di Domenico, Federica Martina Barbagallo, Ignazio Randazzo, Cinzia Lucia Leggio, Gian Marco Galvano, Fabio Grosso, Giuseppe Antioxidants (Basel) Review Hypertension and derived cardiovascular disease (CVD) are among the leading causes of death worldwide. Increased oxidative stress and inflammatory state are involved in different alterations in endothelial functions that contribute to the onset of CVD. Polyphenols, and in particular anthocyanins, have aroused great interest for their antioxidant effects and their cardioprotective role. However, anthocyanins are rarely detected in blood serum because they are primarily metabolized by the gut microbiota. This review presents studies published to date that report the main results from clinical studies on the cardioprotective effects of anthocyanins and the role of the gut microbiota in the metabolism and bioavailability of anthocyanins and their influence on the composition of the microbiota. Even if it seems that anthocyanins have a significant effect on vascular health, more studies are required to better clarify which molecules and doses show vascular benefits without forgetting the crucial role of the microbiota. MDPI 2023-09-18 /pmc/articles/PMC10525277/ /pubmed/37760077 http://dx.doi.org/10.3390/antiox12091773 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Laudani, Samuele
Godos, Justyna
Di Domenico, Federica Martina
Barbagallo, Ignazio
Randazzo, Cinzia Lucia
Leggio, Gian Marco
Galvano, Fabio
Grosso, Giuseppe
Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
title Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
title_full Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
title_fullStr Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
title_full_unstemmed Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
title_short Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
title_sort anthocyanin effects on vascular and endothelial health: evidence from clinical trials and role of gut microbiota metabolites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525277/
https://www.ncbi.nlm.nih.gov/pubmed/37760077
http://dx.doi.org/10.3390/antiox12091773
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