Cargando…

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain haemoglobin gene resulting in the substitution of glutamic acid with valine. This mutation leads to the production of an abnormal h...

Descripción completa

Detalles Bibliográficos
Autores principales: Aboderin, Florence Ifechukwude, Oduola, Taofeeq, Davison, Glenda Mary, Oguntibeju, Oluwafemi Omoniyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525295/
https://www.ncbi.nlm.nih.gov/pubmed/37760854
http://dx.doi.org/10.3390/biomedicines11092413
_version_ 1785110749830447104
author Aboderin, Florence Ifechukwude
Oduola, Taofeeq
Davison, Glenda Mary
Oguntibeju, Oluwafemi Omoniyi
author_facet Aboderin, Florence Ifechukwude
Oduola, Taofeeq
Davison, Glenda Mary
Oguntibeju, Oluwafemi Omoniyi
author_sort Aboderin, Florence Ifechukwude
collection PubMed
description Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain haemoglobin gene resulting in the substitution of glutamic acid with valine. This mutation leads to the production of an abnormal haemoglobin molecule called haemoglobin S (HbS). When deoxygenated, haemoglobin S (HbS) polymerises and results in a sickle-shaped red blood cell which is rigid and has a significantly shortened life span. Various reports have shown a strong link between oxidative stress, inflammation, the immune response, and the pathogenesis of sickle cell disease. The consequence of these processes leads to the development of vasculopathy (disease of the blood vessels) and several other complications. The role of the immune system, particularly the innate immune system, in the pathogenesis of SCD has become increasingly clear in recent years of research; however, little is known about the roles of the adaptive immune system in this disease. This review examines the interaction between the immune system, inflammation, oxidative stress, blood transfusion, and their effects on the pathogenesis of sickle cell anaemia.
format Online
Article
Text
id pubmed-10525295
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105252952023-09-28 A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia Aboderin, Florence Ifechukwude Oduola, Taofeeq Davison, Glenda Mary Oguntibeju, Oluwafemi Omoniyi Biomedicines Review Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain haemoglobin gene resulting in the substitution of glutamic acid with valine. This mutation leads to the production of an abnormal haemoglobin molecule called haemoglobin S (HbS). When deoxygenated, haemoglobin S (HbS) polymerises and results in a sickle-shaped red blood cell which is rigid and has a significantly shortened life span. Various reports have shown a strong link between oxidative stress, inflammation, the immune response, and the pathogenesis of sickle cell disease. The consequence of these processes leads to the development of vasculopathy (disease of the blood vessels) and several other complications. The role of the immune system, particularly the innate immune system, in the pathogenesis of SCD has become increasingly clear in recent years of research; however, little is known about the roles of the adaptive immune system in this disease. This review examines the interaction between the immune system, inflammation, oxidative stress, blood transfusion, and their effects on the pathogenesis of sickle cell anaemia. MDPI 2023-08-29 /pmc/articles/PMC10525295/ /pubmed/37760854 http://dx.doi.org/10.3390/biomedicines11092413 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aboderin, Florence Ifechukwude
Oduola, Taofeeq
Davison, Glenda Mary
Oguntibeju, Oluwafemi Omoniyi
A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia
title A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia
title_full A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia
title_fullStr A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia
title_full_unstemmed A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia
title_short A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia
title_sort review of the relationship between the immune response, inflammation, oxidative stress, and the pathogenesis of sickle cell anaemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525295/
https://www.ncbi.nlm.nih.gov/pubmed/37760854
http://dx.doi.org/10.3390/biomedicines11092413
work_keys_str_mv AT aboderinflorenceifechukwude areviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia
AT oduolataofeeq areviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia
AT davisonglendamary areviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia
AT oguntibejuoluwafemiomoniyi areviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia
AT aboderinflorenceifechukwude reviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia
AT oduolataofeeq reviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia
AT davisonglendamary reviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia
AT oguntibejuoluwafemiomoniyi reviewoftherelationshipbetweentheimmuneresponseinflammationoxidativestressandthepathogenesisofsicklecellanaemia