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Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
Primary intracranial small cell carcinoma (SCC) is extremely rare with only 8 previously reported cases. We describe a case of primary intracranial SCC with intracranial metastasis. A 46-year-old man presented with decreased vision and a red and swollen left eye. Brain magnetic resonance imaging (MR...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525323/ https://www.ncbi.nlm.nih.gov/pubmed/37771442 http://dx.doi.org/10.3389/fonc.2023.1222961 |
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author | Sun, Yesheng Zhang, Ying Li, Ruichun Cai, Dongpeng Zhang, Wei Yang, Zhiqian |
author_facet | Sun, Yesheng Zhang, Ying Li, Ruichun Cai, Dongpeng Zhang, Wei Yang, Zhiqian |
author_sort | Sun, Yesheng |
collection | PubMed |
description | Primary intracranial small cell carcinoma (SCC) is extremely rare with only 8 previously reported cases. We describe a case of primary intracranial SCC with intracranial metastasis. A 46-year-old man presented with decreased vision and a red and swollen left eye. Brain magnetic resonance imaging (MRI) revealed a heterogeneously enhanced tumor on the left frontal lobe. Preoperative systemic computed tomography (CT), MRI, and positron emission tomography (PET)-CT revealed no extracranial tumors. The tumor on the left frontal lobe was excised. Immunohistochemical staining on the excision showed positivity for CD56, synaptophysin (Syn), cytokeratin (CK), and Ki-67 (30%), and negativity for thyroid transcriptional factor-1 (TTF-1), glial fibrillary acidic protein (GFAP), B-cell lymphoma 6 (Bcl-6), multiple myeloma oncogene 1 (MUM-1), C-Myc, Vimentin, P40, P53, CK7, CD3, CD5, CD20, CD79a, CD10, and CD23. The pathological examination strongly suggested that the tumor was a primary intracranial SCC. One year after the surgery, the patient was readmitted with slurred speech and slow movements. Three well-defined tumors were found in the left upper frontal lobe by brain MRI. Tumor resection was then performed. Further immunohistochemical examination of the excised tissue displayed the same pattern as previously, indicating the recurrence of intracranial SCC in the left frontal lobe. The patient received adjuvant chemotherapy and radiotherapy after the tumor resection. At the 2-year follow-up, he remained asymptomatic. |
format | Online Article Text |
id | pubmed-10525323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105253232023-09-28 Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review Sun, Yesheng Zhang, Ying Li, Ruichun Cai, Dongpeng Zhang, Wei Yang, Zhiqian Front Oncol Oncology Primary intracranial small cell carcinoma (SCC) is extremely rare with only 8 previously reported cases. We describe a case of primary intracranial SCC with intracranial metastasis. A 46-year-old man presented with decreased vision and a red and swollen left eye. Brain magnetic resonance imaging (MRI) revealed a heterogeneously enhanced tumor on the left frontal lobe. Preoperative systemic computed tomography (CT), MRI, and positron emission tomography (PET)-CT revealed no extracranial tumors. The tumor on the left frontal lobe was excised. Immunohistochemical staining on the excision showed positivity for CD56, synaptophysin (Syn), cytokeratin (CK), and Ki-67 (30%), and negativity for thyroid transcriptional factor-1 (TTF-1), glial fibrillary acidic protein (GFAP), B-cell lymphoma 6 (Bcl-6), multiple myeloma oncogene 1 (MUM-1), C-Myc, Vimentin, P40, P53, CK7, CD3, CD5, CD20, CD79a, CD10, and CD23. The pathological examination strongly suggested that the tumor was a primary intracranial SCC. One year after the surgery, the patient was readmitted with slurred speech and slow movements. Three well-defined tumors were found in the left upper frontal lobe by brain MRI. Tumor resection was then performed. Further immunohistochemical examination of the excised tissue displayed the same pattern as previously, indicating the recurrence of intracranial SCC in the left frontal lobe. The patient received adjuvant chemotherapy and radiotherapy after the tumor resection. At the 2-year follow-up, he remained asymptomatic. Frontiers Media S.A. 2023-09-13 /pmc/articles/PMC10525323/ /pubmed/37771442 http://dx.doi.org/10.3389/fonc.2023.1222961 Text en Copyright © 2023 Sun, Zhang, Li, Cai, Zhang and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Sun, Yesheng Zhang, Ying Li, Ruichun Cai, Dongpeng Zhang, Wei Yang, Zhiqian Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review |
title | Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review |
title_full | Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review |
title_fullStr | Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review |
title_full_unstemmed | Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review |
title_short | Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review |
title_sort | intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525323/ https://www.ncbi.nlm.nih.gov/pubmed/37771442 http://dx.doi.org/10.3389/fonc.2023.1222961 |
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