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Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review

Primary intracranial small cell carcinoma (SCC) is extremely rare with only 8 previously reported cases. We describe a case of primary intracranial SCC with intracranial metastasis. A 46-year-old man presented with decreased vision and a red and swollen left eye. Brain magnetic resonance imaging (MR...

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Autores principales: Sun, Yesheng, Zhang, Ying, Li, Ruichun, Cai, Dongpeng, Zhang, Wei, Yang, Zhiqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525323/
https://www.ncbi.nlm.nih.gov/pubmed/37771442
http://dx.doi.org/10.3389/fonc.2023.1222961
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author Sun, Yesheng
Zhang, Ying
Li, Ruichun
Cai, Dongpeng
Zhang, Wei
Yang, Zhiqian
author_facet Sun, Yesheng
Zhang, Ying
Li, Ruichun
Cai, Dongpeng
Zhang, Wei
Yang, Zhiqian
author_sort Sun, Yesheng
collection PubMed
description Primary intracranial small cell carcinoma (SCC) is extremely rare with only 8 previously reported cases. We describe a case of primary intracranial SCC with intracranial metastasis. A 46-year-old man presented with decreased vision and a red and swollen left eye. Brain magnetic resonance imaging (MRI) revealed a heterogeneously enhanced tumor on the left frontal lobe. Preoperative systemic computed tomography (CT), MRI, and positron emission tomography (PET)-CT revealed no extracranial tumors. The tumor on the left frontal lobe was excised. Immunohistochemical staining on the excision showed positivity for CD56, synaptophysin (Syn), cytokeratin (CK), and Ki-67 (30%), and negativity for thyroid transcriptional factor-1 (TTF-1), glial fibrillary acidic protein (GFAP), B-cell lymphoma 6 (Bcl-6), multiple myeloma oncogene 1 (MUM-1), C-Myc, Vimentin, P40, P53, CK7, CD3, CD5, CD20, CD79a, CD10, and CD23. The pathological examination strongly suggested that the tumor was a primary intracranial SCC. One year after the surgery, the patient was readmitted with slurred speech and slow movements. Three well-defined tumors were found in the left upper frontal lobe by brain MRI. Tumor resection was then performed. Further immunohistochemical examination of the excised tissue displayed the same pattern as previously, indicating the recurrence of intracranial SCC in the left frontal lobe. The patient received adjuvant chemotherapy and radiotherapy after the tumor resection. At the 2-year follow-up, he remained asymptomatic.
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spelling pubmed-105253232023-09-28 Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review Sun, Yesheng Zhang, Ying Li, Ruichun Cai, Dongpeng Zhang, Wei Yang, Zhiqian Front Oncol Oncology Primary intracranial small cell carcinoma (SCC) is extremely rare with only 8 previously reported cases. We describe a case of primary intracranial SCC with intracranial metastasis. A 46-year-old man presented with decreased vision and a red and swollen left eye. Brain magnetic resonance imaging (MRI) revealed a heterogeneously enhanced tumor on the left frontal lobe. Preoperative systemic computed tomography (CT), MRI, and positron emission tomography (PET)-CT revealed no extracranial tumors. The tumor on the left frontal lobe was excised. Immunohistochemical staining on the excision showed positivity for CD56, synaptophysin (Syn), cytokeratin (CK), and Ki-67 (30%), and negativity for thyroid transcriptional factor-1 (TTF-1), glial fibrillary acidic protein (GFAP), B-cell lymphoma 6 (Bcl-6), multiple myeloma oncogene 1 (MUM-1), C-Myc, Vimentin, P40, P53, CK7, CD3, CD5, CD20, CD79a, CD10, and CD23. The pathological examination strongly suggested that the tumor was a primary intracranial SCC. One year after the surgery, the patient was readmitted with slurred speech and slow movements. Three well-defined tumors were found in the left upper frontal lobe by brain MRI. Tumor resection was then performed. Further immunohistochemical examination of the excised tissue displayed the same pattern as previously, indicating the recurrence of intracranial SCC in the left frontal lobe. The patient received adjuvant chemotherapy and radiotherapy after the tumor resection. At the 2-year follow-up, he remained asymptomatic. Frontiers Media S.A. 2023-09-13 /pmc/articles/PMC10525323/ /pubmed/37771442 http://dx.doi.org/10.3389/fonc.2023.1222961 Text en Copyright © 2023 Sun, Zhang, Li, Cai, Zhang and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sun, Yesheng
Zhang, Ying
Li, Ruichun
Cai, Dongpeng
Zhang, Wei
Yang, Zhiqian
Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
title Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
title_full Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
title_fullStr Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
title_full_unstemmed Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
title_short Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
title_sort intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525323/
https://www.ncbi.nlm.nih.gov/pubmed/37771442
http://dx.doi.org/10.3389/fonc.2023.1222961
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