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Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders
Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant transformation. It is believed that diet can modulate...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525385/ https://www.ncbi.nlm.nih.gov/pubmed/37759977 http://dx.doi.org/10.3390/antiox12091674 |
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author | Cancemi, Gabriella Cicero, Nicola Allegra, Alessandro Gangemi, Sebastiano |
author_facet | Cancemi, Gabriella Cicero, Nicola Allegra, Alessandro Gangemi, Sebastiano |
author_sort | Cancemi, Gabriella |
collection | PubMed |
description | Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant transformation. It is believed that diet can modulate cellular redox state and that oxidative stress is implicated in lymphomagenesis by acting on several biological mechanisms; in fact, oxidative stress can generate a state of chronic inflammation through the activation of various transcription factors, thereby increasing the production of proinflammatory cytokines and causing overstimulation of B lymphocytes in the production of antibodies and possible alterations in cellular DNA. The purpose of our work is to investigate the results of in vitro and in vivo studies on the possible interaction between lymphomas, oxidative stress, and diet. A variety of dietary regimens and substances introduced with the diet that may have antioxidant and antiproliferative effects were assessed. The possibility of using nutraceuticals as novel anticancer agents is discussed; although the use of natural substances in lymphoma therapy is an interesting field of study, further studies are needed to define the efficacy of different nutraceuticals before introducing them into clinical practice. |
format | Online Article Text |
id | pubmed-10525385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105253852023-09-28 Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders Cancemi, Gabriella Cicero, Nicola Allegra, Alessandro Gangemi, Sebastiano Antioxidants (Basel) Review Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant transformation. It is believed that diet can modulate cellular redox state and that oxidative stress is implicated in lymphomagenesis by acting on several biological mechanisms; in fact, oxidative stress can generate a state of chronic inflammation through the activation of various transcription factors, thereby increasing the production of proinflammatory cytokines and causing overstimulation of B lymphocytes in the production of antibodies and possible alterations in cellular DNA. The purpose of our work is to investigate the results of in vitro and in vivo studies on the possible interaction between lymphomas, oxidative stress, and diet. A variety of dietary regimens and substances introduced with the diet that may have antioxidant and antiproliferative effects were assessed. The possibility of using nutraceuticals as novel anticancer agents is discussed; although the use of natural substances in lymphoma therapy is an interesting field of study, further studies are needed to define the efficacy of different nutraceuticals before introducing them into clinical practice. MDPI 2023-08-26 /pmc/articles/PMC10525385/ /pubmed/37759977 http://dx.doi.org/10.3390/antiox12091674 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cancemi, Gabriella Cicero, Nicola Allegra, Alessandro Gangemi, Sebastiano Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders |
title | Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders |
title_full | Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders |
title_fullStr | Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders |
title_full_unstemmed | Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders |
title_short | Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders |
title_sort | effect of diet and oxidative stress in the pathogenesis of lymphoproliferative disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525385/ https://www.ncbi.nlm.nih.gov/pubmed/37759977 http://dx.doi.org/10.3390/antiox12091674 |
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