Cargando…
RUNX1-Regulated Signaling Pathways in Ovarian Cancer
Ovarian cancer is the leading cause of gynecological death worldwide, and its poor prognosis and high mortality seriously affect the life of ovarian cancer patients. Runt-related transcription factor 1 (RUNX1) has been widely studied in hematological diseases and plays an important role in the occur...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525517/ https://www.ncbi.nlm.nih.gov/pubmed/37760803 http://dx.doi.org/10.3390/biomedicines11092357 |
_version_ | 1785110803316211712 |
---|---|
author | Chen, Yuanzhi He, Yingying Liu, Shubai |
author_facet | Chen, Yuanzhi He, Yingying Liu, Shubai |
author_sort | Chen, Yuanzhi |
collection | PubMed |
description | Ovarian cancer is the leading cause of gynecological death worldwide, and its poor prognosis and high mortality seriously affect the life of ovarian cancer patients. Runt-related transcription factor 1 (RUNX1) has been widely studied in hematological diseases and plays an important role in the occurrence and development of hematological diseases. In recent years, studies have reported the roles of RUNX1 in solid tumors, including the significantly increased expression of RUNX1 in ovarian cancer. In ovarian cancer, the dysregulation of the RUNX1 signaling pathway has been implicated in tumor progression, metastasis, and response to therapy. At the same time, the decreased expression of RUNX1 in ovarian cancer can significantly improve the sensitivity of clinical chemotherapy and provide theoretical support for the subsequent diagnosis and treatment target of ovarian cancer, providing prognosis and treatment options to patients with ovarian cancer. However, the role of RUNX1 in ovarian cancer remains unclear. Therefore, this article reviews the relationship between RUNX1 and the occurrence and development of ovarian cancer, as well as the closely regulated signaling pathways, to provide some inspiration and theoretical support for future research on RUNX1 in ovarian cancer and other diseases. |
format | Online Article Text |
id | pubmed-10525517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105255172023-09-28 RUNX1-Regulated Signaling Pathways in Ovarian Cancer Chen, Yuanzhi He, Yingying Liu, Shubai Biomedicines Review Ovarian cancer is the leading cause of gynecological death worldwide, and its poor prognosis and high mortality seriously affect the life of ovarian cancer patients. Runt-related transcription factor 1 (RUNX1) has been widely studied in hematological diseases and plays an important role in the occurrence and development of hematological diseases. In recent years, studies have reported the roles of RUNX1 in solid tumors, including the significantly increased expression of RUNX1 in ovarian cancer. In ovarian cancer, the dysregulation of the RUNX1 signaling pathway has been implicated in tumor progression, metastasis, and response to therapy. At the same time, the decreased expression of RUNX1 in ovarian cancer can significantly improve the sensitivity of clinical chemotherapy and provide theoretical support for the subsequent diagnosis and treatment target of ovarian cancer, providing prognosis and treatment options to patients with ovarian cancer. However, the role of RUNX1 in ovarian cancer remains unclear. Therefore, this article reviews the relationship between RUNX1 and the occurrence and development of ovarian cancer, as well as the closely regulated signaling pathways, to provide some inspiration and theoretical support for future research on RUNX1 in ovarian cancer and other diseases. MDPI 2023-08-23 /pmc/articles/PMC10525517/ /pubmed/37760803 http://dx.doi.org/10.3390/biomedicines11092357 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Yuanzhi He, Yingying Liu, Shubai RUNX1-Regulated Signaling Pathways in Ovarian Cancer |
title | RUNX1-Regulated Signaling Pathways in Ovarian Cancer |
title_full | RUNX1-Regulated Signaling Pathways in Ovarian Cancer |
title_fullStr | RUNX1-Regulated Signaling Pathways in Ovarian Cancer |
title_full_unstemmed | RUNX1-Regulated Signaling Pathways in Ovarian Cancer |
title_short | RUNX1-Regulated Signaling Pathways in Ovarian Cancer |
title_sort | runx1-regulated signaling pathways in ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525517/ https://www.ncbi.nlm.nih.gov/pubmed/37760803 http://dx.doi.org/10.3390/biomedicines11092357 |
work_keys_str_mv | AT chenyuanzhi runx1regulatedsignalingpathwaysinovariancancer AT heyingying runx1regulatedsignalingpathwaysinovariancancer AT liushubai runx1regulatedsignalingpathwaysinovariancancer |