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Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity

The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship betwe...

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Autores principales: González-Vidal, Alejandro, Mercado-Sáenz, Silvia, Burgos-Molina, Antonio M., Alamilla-Presuel, Juan C., Alcaraz, Miguel, Sendra-Portero, Francisco, Ruiz-Gómez, Miguel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525530/
https://www.ncbi.nlm.nih.gov/pubmed/37759994
http://dx.doi.org/10.3390/antiox12091690
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author González-Vidal, Alejandro
Mercado-Sáenz, Silvia
Burgos-Molina, Antonio M.
Alamilla-Presuel, Juan C.
Alcaraz, Miguel
Sendra-Portero, Francisco
Ruiz-Gómez, Miguel J.
author_facet González-Vidal, Alejandro
Mercado-Sáenz, Silvia
Burgos-Molina, Antonio M.
Alamilla-Presuel, Juan C.
Alcaraz, Miguel
Sendra-Portero, Francisco
Ruiz-Gómez, Miguel J.
author_sort González-Vidal, Alejandro
collection PubMed
description The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship between resistance/response to ionizing radiation, cellular aging, and the response mechanisms to oxidative stress, free radicals, reactive oxygen species (ROS), and antioxidant activity in the yeast S. cerevisiae. Systems biology allows us to use tools that reveal the molecular mechanisms common to different cellular response phenomena. The results found indicate that homologous recombination, non-homologous end joining, and base excision repair pathways are the most important common processes necessary to maintain cellular homeostasis. The metabolic routes of longevity regulation are those that jointly contribute to the three phenomena studied. This study proposes eleven common biomarkers for response/resistance to ionizing radiation and aging (EXO1, MEC1, MRE11, RAD27, RAD50, RAD51, RAD52, RAD55, RAD9, SGS1, YKU70) and two biomarkers for response/resistance to radiation and oxidative stress, free radicals, ROS, and antioxidant activity (NTG1, OGG1). In addition, it is important to highlight that the HSP104 protein could be a good biomarker common to the three phenomena studied.
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spelling pubmed-105255302023-09-28 Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity González-Vidal, Alejandro Mercado-Sáenz, Silvia Burgos-Molina, Antonio M. Alamilla-Presuel, Juan C. Alcaraz, Miguel Sendra-Portero, Francisco Ruiz-Gómez, Miguel J. Antioxidants (Basel) Article The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship between resistance/response to ionizing radiation, cellular aging, and the response mechanisms to oxidative stress, free radicals, reactive oxygen species (ROS), and antioxidant activity in the yeast S. cerevisiae. Systems biology allows us to use tools that reveal the molecular mechanisms common to different cellular response phenomena. The results found indicate that homologous recombination, non-homologous end joining, and base excision repair pathways are the most important common processes necessary to maintain cellular homeostasis. The metabolic routes of longevity regulation are those that jointly contribute to the three phenomena studied. This study proposes eleven common biomarkers for response/resistance to ionizing radiation and aging (EXO1, MEC1, MRE11, RAD27, RAD50, RAD51, RAD52, RAD55, RAD9, SGS1, YKU70) and two biomarkers for response/resistance to radiation and oxidative stress, free radicals, ROS, and antioxidant activity (NTG1, OGG1). In addition, it is important to highlight that the HSP104 protein could be a good biomarker common to the three phenomena studied. MDPI 2023-08-30 /pmc/articles/PMC10525530/ /pubmed/37759994 http://dx.doi.org/10.3390/antiox12091690 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
González-Vidal, Alejandro
Mercado-Sáenz, Silvia
Burgos-Molina, Antonio M.
Alamilla-Presuel, Juan C.
Alcaraz, Miguel
Sendra-Portero, Francisco
Ruiz-Gómez, Miguel J.
Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity
title Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity
title_full Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity
title_fullStr Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity
title_full_unstemmed Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity
title_short Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity
title_sort molecular mechanisms of resistance to ionizing radiation in s. cerevisiae and its relationship with aging, oxidative stress, and antioxidant activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525530/
https://www.ncbi.nlm.nih.gov/pubmed/37759994
http://dx.doi.org/10.3390/antiox12091690
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