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Biomarkers for Kidney-Transplant Rejection: A Short Review Study

Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Inves...

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Autores principales: Sharaby, Israa, Alksas, Ahmed, Abou El-Ghar, Mohamed, Eldeeb, Mona, Ghazal, Mohammed, Gondim, Dibson, El-Baz, Ayman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525551/
https://www.ncbi.nlm.nih.gov/pubmed/37760879
http://dx.doi.org/10.3390/biomedicines11092437
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author Sharaby, Israa
Alksas, Ahmed
Abou El-Ghar, Mohamed
Eldeeb, Mona
Ghazal, Mohammed
Gondim, Dibson
El-Baz, Ayman
author_facet Sharaby, Israa
Alksas, Ahmed
Abou El-Ghar, Mohamed
Eldeeb, Mona
Ghazal, Mohammed
Gondim, Dibson
El-Baz, Ayman
author_sort Sharaby, Israa
collection PubMed
description Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients.
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spelling pubmed-105255512023-09-28 Biomarkers for Kidney-Transplant Rejection: A Short Review Study Sharaby, Israa Alksas, Ahmed Abou El-Ghar, Mohamed Eldeeb, Mona Ghazal, Mohammed Gondim, Dibson El-Baz, Ayman Biomedicines Review Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients. MDPI 2023-08-31 /pmc/articles/PMC10525551/ /pubmed/37760879 http://dx.doi.org/10.3390/biomedicines11092437 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sharaby, Israa
Alksas, Ahmed
Abou El-Ghar, Mohamed
Eldeeb, Mona
Ghazal, Mohammed
Gondim, Dibson
El-Baz, Ayman
Biomarkers for Kidney-Transplant Rejection: A Short Review Study
title Biomarkers for Kidney-Transplant Rejection: A Short Review Study
title_full Biomarkers for Kidney-Transplant Rejection: A Short Review Study
title_fullStr Biomarkers for Kidney-Transplant Rejection: A Short Review Study
title_full_unstemmed Biomarkers for Kidney-Transplant Rejection: A Short Review Study
title_short Biomarkers for Kidney-Transplant Rejection: A Short Review Study
title_sort biomarkers for kidney-transplant rejection: a short review study
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525551/
https://www.ncbi.nlm.nih.gov/pubmed/37760879
http://dx.doi.org/10.3390/biomedicines11092437
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