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Biomarkers for Kidney-Transplant Rejection: A Short Review Study
Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Inves...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525551/ https://www.ncbi.nlm.nih.gov/pubmed/37760879 http://dx.doi.org/10.3390/biomedicines11092437 |
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author | Sharaby, Israa Alksas, Ahmed Abou El-Ghar, Mohamed Eldeeb, Mona Ghazal, Mohammed Gondim, Dibson El-Baz, Ayman |
author_facet | Sharaby, Israa Alksas, Ahmed Abou El-Ghar, Mohamed Eldeeb, Mona Ghazal, Mohammed Gondim, Dibson El-Baz, Ayman |
author_sort | Sharaby, Israa |
collection | PubMed |
description | Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients. |
format | Online Article Text |
id | pubmed-10525551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105255512023-09-28 Biomarkers for Kidney-Transplant Rejection: A Short Review Study Sharaby, Israa Alksas, Ahmed Abou El-Ghar, Mohamed Eldeeb, Mona Ghazal, Mohammed Gondim, Dibson El-Baz, Ayman Biomedicines Review Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients. MDPI 2023-08-31 /pmc/articles/PMC10525551/ /pubmed/37760879 http://dx.doi.org/10.3390/biomedicines11092437 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sharaby, Israa Alksas, Ahmed Abou El-Ghar, Mohamed Eldeeb, Mona Ghazal, Mohammed Gondim, Dibson El-Baz, Ayman Biomarkers for Kidney-Transplant Rejection: A Short Review Study |
title | Biomarkers for Kidney-Transplant Rejection: A Short Review Study |
title_full | Biomarkers for Kidney-Transplant Rejection: A Short Review Study |
title_fullStr | Biomarkers for Kidney-Transplant Rejection: A Short Review Study |
title_full_unstemmed | Biomarkers for Kidney-Transplant Rejection: A Short Review Study |
title_short | Biomarkers for Kidney-Transplant Rejection: A Short Review Study |
title_sort | biomarkers for kidney-transplant rejection: a short review study |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525551/ https://www.ncbi.nlm.nih.gov/pubmed/37760879 http://dx.doi.org/10.3390/biomedicines11092437 |
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