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Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis

(1) Background: Coagulase-negative staphylococci (CoNS) are an important group of organisms that can cause bloodstream infection (BSI) and infective endocarditis (IE). The prevalence of IE in patients with BSI due to different CoNS species, however, has received limited attention; (2) Methods: A ret...

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Autores principales: Haddad, Sara F., Lahr, Brian D., Patarroyo, Sebastian Santos, Chesdachai, Supavit, Kies, Kami D., O’Horo, John C., DeSimone, Daniel C., Sendi, Parham, Baddour, Larry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525567/
https://www.ncbi.nlm.nih.gov/pubmed/37760749
http://dx.doi.org/10.3390/antibiotics12091453
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author Haddad, Sara F.
Lahr, Brian D.
Patarroyo, Sebastian Santos
Chesdachai, Supavit
Kies, Kami D.
O’Horo, John C.
DeSimone, Daniel C.
Sendi, Parham
Baddour, Larry M.
author_facet Haddad, Sara F.
Lahr, Brian D.
Patarroyo, Sebastian Santos
Chesdachai, Supavit
Kies, Kami D.
O’Horo, John C.
DeSimone, Daniel C.
Sendi, Parham
Baddour, Larry M.
author_sort Haddad, Sara F.
collection PubMed
description (1) Background: Coagulase-negative staphylococci (CoNS) are an important group of organisms that can cause bloodstream infection (BSI) and infective endocarditis (IE). The prevalence of IE in patients with BSI due to different CoNS species, however, has received limited attention; (2) Methods: A retrospective study of adults with monomicrobial CoNS BSI who had undergone echocardiography and a risk factor analysis was done to determine the most common CoNS species that cause definite IE; (3) Results: 247 patients with CoNS BSI were included in the investigation; 49 (19.8%) had definite IE, 124 (50.2%) possible IE, and 74 (30.0%) BSI only. The latter two entities were grouped in one category for further analysis. The most common species in CoNS BSI was Staphylococcus epidermidis (79.4%) and most patients (83.2%) had possible IE/BSI only. 59.1% of patients with BSI due to S. lugdunensis had definite IE. The majority of CoNS were healthcare-associated/nosocomial bacteremia. Multivariable analysis demonstrated that valve disease (p = 0.002) and a foreign cardiovascular material (p < 0.001) were risk factors associated with definite IE. Patients with S. lugdunensis BSI had an 8-fold higher risk of definite IE than did those with S. epidermidis BSI and nearly a 13-fold higher risk than did patients with BSI due to other species of CoNS (p = 0.002); (4) Conclusions: The prevalence of definite IE in patients with BSI due to different CoNS species was significant. CoNS bacteremia, particularly with S. lugdunensis, confers a significant risk of IE, particularly in patients with a valve disease or intravascular foreign body material and should not be immediately dismissed as a contaminant.
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spelling pubmed-105255672023-09-28 Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis Haddad, Sara F. Lahr, Brian D. Patarroyo, Sebastian Santos Chesdachai, Supavit Kies, Kami D. O’Horo, John C. DeSimone, Daniel C. Sendi, Parham Baddour, Larry M. Antibiotics (Basel) Article (1) Background: Coagulase-negative staphylococci (CoNS) are an important group of organisms that can cause bloodstream infection (BSI) and infective endocarditis (IE). The prevalence of IE in patients with BSI due to different CoNS species, however, has received limited attention; (2) Methods: A retrospective study of adults with monomicrobial CoNS BSI who had undergone echocardiography and a risk factor analysis was done to determine the most common CoNS species that cause definite IE; (3) Results: 247 patients with CoNS BSI were included in the investigation; 49 (19.8%) had definite IE, 124 (50.2%) possible IE, and 74 (30.0%) BSI only. The latter two entities were grouped in one category for further analysis. The most common species in CoNS BSI was Staphylococcus epidermidis (79.4%) and most patients (83.2%) had possible IE/BSI only. 59.1% of patients with BSI due to S. lugdunensis had definite IE. The majority of CoNS were healthcare-associated/nosocomial bacteremia. Multivariable analysis demonstrated that valve disease (p = 0.002) and a foreign cardiovascular material (p < 0.001) were risk factors associated with definite IE. Patients with S. lugdunensis BSI had an 8-fold higher risk of definite IE than did those with S. epidermidis BSI and nearly a 13-fold higher risk than did patients with BSI due to other species of CoNS (p = 0.002); (4) Conclusions: The prevalence of definite IE in patients with BSI due to different CoNS species was significant. CoNS bacteremia, particularly with S. lugdunensis, confers a significant risk of IE, particularly in patients with a valve disease or intravascular foreign body material and should not be immediately dismissed as a contaminant. MDPI 2023-09-18 /pmc/articles/PMC10525567/ /pubmed/37760749 http://dx.doi.org/10.3390/antibiotics12091453 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haddad, Sara F.
Lahr, Brian D.
Patarroyo, Sebastian Santos
Chesdachai, Supavit
Kies, Kami D.
O’Horo, John C.
DeSimone, Daniel C.
Sendi, Parham
Baddour, Larry M.
Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis
title Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis
title_full Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis
title_fullStr Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis
title_full_unstemmed Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis
title_short Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis
title_sort bloodstream infection due to coagulase-negative staphylococci: impact of species on prevalence of infective endocarditis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525567/
https://www.ncbi.nlm.nih.gov/pubmed/37760749
http://dx.doi.org/10.3390/antibiotics12091453
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