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The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts

In our previous research, we demonstrated that honey and its biomimetic natural deep eutectic solvent (NaDES) modulate the antioxidant activity (AOA) of the raspberry extract (RE). In this study, we evaluated the AOA behaviour of the mixture honey/NaDES–honeysuckle (Lonicera caprifolium, LFL) extrac...

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Detalles Bibliográficos
Autores principales: Dimitriu, Luminița, Constantinescu-Aruxandei, Diana, Preda, Daniel, Moraru, Ionuț, Băbeanu, Narcisa Elena, Oancea, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525646/
https://www.ncbi.nlm.nih.gov/pubmed/37759982
http://dx.doi.org/10.3390/antiox12091678
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author Dimitriu, Luminița
Constantinescu-Aruxandei, Diana
Preda, Daniel
Moraru, Ionuț
Băbeanu, Narcisa Elena
Oancea, Florin
author_facet Dimitriu, Luminița
Constantinescu-Aruxandei, Diana
Preda, Daniel
Moraru, Ionuț
Băbeanu, Narcisa Elena
Oancea, Florin
author_sort Dimitriu, Luminița
collection PubMed
description In our previous research, we demonstrated that honey and its biomimetic natural deep eutectic solvent (NaDES) modulate the antioxidant activity (AOA) of the raspberry extract (RE). In this study, we evaluated the AOA behaviour of the mixture honey/NaDES–honeysuckle (Lonicera caprifolium, LFL) extract and compared it with the mixture honey/NaDES–RE. These two extracts have similar major flavonoids and hydroxycinnamic acid compounds but differ in their total content and the presence of anthocyanins in RE. Therefore, it was of interest to see if the modulation of the LFL polyphenols by honey/NaDES was similar to that of RE. We also evaluated the prebiotic activity of these mixtures and individual components on Limosilactobacillus reuteri DSM 20016. Although honey/NaDES modulated the AOA of both extracts, from synergism to antagonism, the modulation was different between the two extracts for some AOA activities. Honey/NaDES mixtures enriched with LFL and RE did not show significant differences in bacterial growth stimulation. However, at a concentration of 45 mg/mL, the honey -LFL mixture exhibited a higher effect compared to the honey–RE mixture. The antioxidant and prebiotic properties of mixtures between honey and polyphenol-rich extracts are determined by multiple interactions in complex chemical systems.
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spelling pubmed-105256462023-09-28 The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts Dimitriu, Luminița Constantinescu-Aruxandei, Diana Preda, Daniel Moraru, Ionuț Băbeanu, Narcisa Elena Oancea, Florin Antioxidants (Basel) Article In our previous research, we demonstrated that honey and its biomimetic natural deep eutectic solvent (NaDES) modulate the antioxidant activity (AOA) of the raspberry extract (RE). In this study, we evaluated the AOA behaviour of the mixture honey/NaDES–honeysuckle (Lonicera caprifolium, LFL) extract and compared it with the mixture honey/NaDES–RE. These two extracts have similar major flavonoids and hydroxycinnamic acid compounds but differ in their total content and the presence of anthocyanins in RE. Therefore, it was of interest to see if the modulation of the LFL polyphenols by honey/NaDES was similar to that of RE. We also evaluated the prebiotic activity of these mixtures and individual components on Limosilactobacillus reuteri DSM 20016. Although honey/NaDES modulated the AOA of both extracts, from synergism to antagonism, the modulation was different between the two extracts for some AOA activities. Honey/NaDES mixtures enriched with LFL and RE did not show significant differences in bacterial growth stimulation. However, at a concentration of 45 mg/mL, the honey -LFL mixture exhibited a higher effect compared to the honey–RE mixture. The antioxidant and prebiotic properties of mixtures between honey and polyphenol-rich extracts are determined by multiple interactions in complex chemical systems. MDPI 2023-08-28 /pmc/articles/PMC10525646/ /pubmed/37759982 http://dx.doi.org/10.3390/antiox12091678 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dimitriu, Luminița
Constantinescu-Aruxandei, Diana
Preda, Daniel
Moraru, Ionuț
Băbeanu, Narcisa Elena
Oancea, Florin
The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts
title The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts
title_full The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts
title_fullStr The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts
title_full_unstemmed The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts
title_short The Antioxidant and Prebiotic Activities of Mixtures Honey/Biomimetic NaDES and Polyphenols Show Differences between Honeysuckle and Raspberry Extracts
title_sort antioxidant and prebiotic activities of mixtures honey/biomimetic nades and polyphenols show differences between honeysuckle and raspberry extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525646/
https://www.ncbi.nlm.nih.gov/pubmed/37759982
http://dx.doi.org/10.3390/antiox12091678
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