Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation

SIMPLE SUMMARY: We previously developed a novel model of progressive multiple sclerosis, called progressive experimental autoimmune encephalomyelitis, in mice with oligodendroglia-specific knockout of the connexin-47 gene. Our previous research showed that iguratimod, an antirheumatic drug, effectiv...

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Detalles Bibliográficos
Autores principales: Nagata, Satoshi, Yamasaki, Ryo, Takase, Ezgi Ozdemir, Iida, Kotaro, Watanabe, Mitsuru, Masaki, Katsuhisa, Wijering, Marion Heleen Cathérine, Yamaguchi, Hiroo, Kira, Jun-ichi, Isobe, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525689/
https://www.ncbi.nlm.nih.gov/pubmed/37759616
http://dx.doi.org/10.3390/biology12091217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525689/
https://www.ncbi.nlm.nih.gov/pubmed/37759616
http://dx.doi.org/10.3390/biology12091217

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