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Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China

Background: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical...

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Autores principales: Zhou, Siqi, Xiao, Shuzhen, Wang, Xuedong, Wang, Xuefeng, Han, Lizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525729/
https://www.ncbi.nlm.nih.gov/pubmed/37760728
http://dx.doi.org/10.3390/antibiotics12091432
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author Zhou, Siqi
Xiao, Shuzhen
Wang, Xuedong
Wang, Xuefeng
Han, Lizhong
author_facet Zhou, Siqi
Xiao, Shuzhen
Wang, Xuedong
Wang, Xuefeng
Han, Lizhong
author_sort Zhou, Siqi
collection PubMed
description Background: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical variables of all qualified patients admitted to burn wards were analyzed retrospectively in 2021 at a tertiary hospital in eastern China through univariate analysis and multivariate logistic regression. The Kaplan–Meier method was also used for plotting survival curves. Isolates and resistance data were evaluated to demonstrate the evolution of targeted antibiotics of strains from BWI. Results: A total of 580 (median age, 39.5 years (23–56 years); 372/580 (64.14%) male) patients were evaluated, 348 (60.0%) of whom experienced BWI. A variety of factors are associated with BWI. Multivariate logistic regression analysis showed that depth and area of burn and duration from burn to first hospitalization are independent risk factors for BWI. For BWI onset in these patients, 47.24% (274/580) occurred in the first week. The most frequently isolated causative organism was Staphylococcus aureus (15.7%) in patients with BWI. The duration of transition from Gram-positive strains (median 3 days, (2–7 days)) to Gram-negative (median 10 days, (4–17 days)) ones isolated from burn wound shrunk. Hospital length of stay was considered as a protective factor for BWI. Conclusion: The precise assessment of factors affecting BWI in burn patients enhances prompt and suitable management. Swab cultures for surveillance could be utilized to monitor the microbiological status of burn patients.
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spelling pubmed-105257292023-09-28 Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China Zhou, Siqi Xiao, Shuzhen Wang, Xuedong Wang, Xuefeng Han, Lizhong Antibiotics (Basel) Article Background: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical variables of all qualified patients admitted to burn wards were analyzed retrospectively in 2021 at a tertiary hospital in eastern China through univariate analysis and multivariate logistic regression. The Kaplan–Meier method was also used for plotting survival curves. Isolates and resistance data were evaluated to demonstrate the evolution of targeted antibiotics of strains from BWI. Results: A total of 580 (median age, 39.5 years (23–56 years); 372/580 (64.14%) male) patients were evaluated, 348 (60.0%) of whom experienced BWI. A variety of factors are associated with BWI. Multivariate logistic regression analysis showed that depth and area of burn and duration from burn to first hospitalization are independent risk factors for BWI. For BWI onset in these patients, 47.24% (274/580) occurred in the first week. The most frequently isolated causative organism was Staphylococcus aureus (15.7%) in patients with BWI. The duration of transition from Gram-positive strains (median 3 days, (2–7 days)) to Gram-negative (median 10 days, (4–17 days)) ones isolated from burn wound shrunk. Hospital length of stay was considered as a protective factor for BWI. Conclusion: The precise assessment of factors affecting BWI in burn patients enhances prompt and suitable management. Swab cultures for surveillance could be utilized to monitor the microbiological status of burn patients. MDPI 2023-09-11 /pmc/articles/PMC10525729/ /pubmed/37760728 http://dx.doi.org/10.3390/antibiotics12091432 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Siqi
Xiao, Shuzhen
Wang, Xuedong
Wang, Xuefeng
Han, Lizhong
Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China
title Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China
title_full Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China
title_fullStr Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China
title_full_unstemmed Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China
title_short Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China
title_sort risk factors and pathogens of wound infection in burn inpatients from east china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525729/
https://www.ncbi.nlm.nih.gov/pubmed/37760728
http://dx.doi.org/10.3390/antibiotics12091432
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