Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review

Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reaction...

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Detalles Bibliográficos
Autores principales: Sekulovski, Metodija, Mileva, Niya, Chervenkov, Lyubomir, Peshevska-Sekulovska, Monika, Vasilev, Georgi Vasilev, Vasilev, Georgi Hristov, Miteva, Dimitrina, Tomov, Latchezar, Lazova, Snezhina, Gulinac, Milena, Velikova, Tsvetelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525846/
https://www.ncbi.nlm.nih.gov/pubmed/37760899
http://dx.doi.org/10.3390/biomedicines11092458
Descripción
Sumario:Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED.

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