Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review

Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reaction...

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Autores principales: Sekulovski, Metodija, Mileva, Niya, Chervenkov, Lyubomir, Peshevska-Sekulovska, Monika, Vasilev, Georgi Vasilev, Vasilev, Georgi Hristov, Miteva, Dimitrina, Tomov, Latchezar, Lazova, Snezhina, Gulinac, Milena, Velikova, Tsvetelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525846/
https://www.ncbi.nlm.nih.gov/pubmed/37760899
http://dx.doi.org/10.3390/biomedicines11092458
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author Sekulovski, Metodija
Mileva, Niya
Chervenkov, Lyubomir
Peshevska-Sekulovska, Monika
Vasilev, Georgi Vasilev
Vasilev, Georgi Hristov
Miteva, Dimitrina
Tomov, Latchezar
Lazova, Snezhina
Gulinac, Milena
Velikova, Tsvetelina
author_facet Sekulovski, Metodija
Mileva, Niya
Chervenkov, Lyubomir
Peshevska-Sekulovska, Monika
Vasilev, Georgi Vasilev
Vasilev, Georgi Hristov
Miteva, Dimitrina
Tomov, Latchezar
Lazova, Snezhina
Gulinac, Milena
Velikova, Tsvetelina
author_sort Sekulovski, Metodija
collection PubMed
description Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED.
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spelling pubmed-105258462023-09-28 Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review Sekulovski, Metodija Mileva, Niya Chervenkov, Lyubomir Peshevska-Sekulovska, Monika Vasilev, Georgi Vasilev Vasilev, Georgi Hristov Miteva, Dimitrina Tomov, Latchezar Lazova, Snezhina Gulinac, Milena Velikova, Tsvetelina Biomedicines Review Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED. MDPI 2023-09-04 /pmc/articles/PMC10525846/ /pubmed/37760899 http://dx.doi.org/10.3390/biomedicines11092458 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sekulovski, Metodija
Mileva, Niya
Chervenkov, Lyubomir
Peshevska-Sekulovska, Monika
Vasilev, Georgi Vasilev
Vasilev, Georgi Hristov
Miteva, Dimitrina
Tomov, Latchezar
Lazova, Snezhina
Gulinac, Milena
Velikova, Tsvetelina
Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review
title Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review
title_full Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review
title_fullStr Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review
title_full_unstemmed Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review
title_short Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review
title_sort endothelial dysfunction and pregnant covid-19 patients with thrombophilia: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525846/
https://www.ncbi.nlm.nih.gov/pubmed/37760899
http://dx.doi.org/10.3390/biomedicines11092458
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