Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues. On-target/off-tumor binding of therapeutics results in significant pharmacokinetic and pharmacodynamic...

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Detalles Bibliográficos
Autores principales: Smith, F. Donelson, Pierce, Robert H., Thisted, Thomas, van der Horst, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525963/
https://www.ncbi.nlm.nih.gov/pubmed/37753969
http://dx.doi.org/10.3390/antib12030055

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