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Blood-Biomarkers for Glucose Metabolism in Preterm Infants

This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal ill...

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Autores principales: Bjerager, Mia O., Hansen, Bo M., Sørensen, Frederik, Petersen, Jes R., Jensen, Kristian V., Hjelvang, Brian R., Hvelplund, Anna C., Olsen, Dorte A., Nielsen, Aneta A., Forman, Julie L., Brandslund, Ivan, Greisen, Gorm, Slidsborg, Carina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525969/
https://www.ncbi.nlm.nih.gov/pubmed/37760819
http://dx.doi.org/10.3390/biomedicines11092377
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author Bjerager, Mia O.
Hansen, Bo M.
Sørensen, Frederik
Petersen, Jes R.
Jensen, Kristian V.
Hjelvang, Brian R.
Hvelplund, Anna C.
Olsen, Dorte A.
Nielsen, Aneta A.
Forman, Julie L.
Brandslund, Ivan
Greisen, Gorm
Slidsborg, Carina
author_facet Bjerager, Mia O.
Hansen, Bo M.
Sørensen, Frederik
Petersen, Jes R.
Jensen, Kristian V.
Hjelvang, Brian R.
Hvelplund, Anna C.
Olsen, Dorte A.
Nielsen, Aneta A.
Forman, Julie L.
Brandslund, Ivan
Greisen, Gorm
Slidsborg, Carina
author_sort Bjerager, Mia O.
collection PubMed
description This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018–2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system. Thirty-four “healthy” preterm infants (31%) were identified. The “ill” infants were divided into four subgroups dependent on gestational age and small for gestational age. Reference levels for the growth parameters and metabolic biomarkers glucose, albumin, and adiponectin, and two glucose control indicators, glycated albumin and fructosamine, were determined for the “healthy” and “ill” subgroups. The “ill” extremely preterm infants had increased glucose levels (mean difference 0.71 mmol/L, 95% CI 0.23; 1.18 mmol/L) and glycated albumin (corrected; %) (mean difference 0.92 mmol/L, 95% CI 0.38 mmol/L;1.47 mmol/L) compared to the “healthy” infants. In “ill” extremely preterm infants and “ill” very preterm infants born small for gestational age, levels of biomarkers containing proteins were decreased. In the “Ill” extremely preterm infants and infants born small for gestational age, postnatal growth was continuously decreased throughout the postconceptional period. The short-term glucose-control indicator, glycated albumin (corrected; %), reflected well the high glucose levels due to its correction for the depleted plasma-protein pool.
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spelling pubmed-105259692023-09-28 Blood-Biomarkers for Glucose Metabolism in Preterm Infants Bjerager, Mia O. Hansen, Bo M. Sørensen, Frederik Petersen, Jes R. Jensen, Kristian V. Hjelvang, Brian R. Hvelplund, Anna C. Olsen, Dorte A. Nielsen, Aneta A. Forman, Julie L. Brandslund, Ivan Greisen, Gorm Slidsborg, Carina Biomedicines Article This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018–2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system. Thirty-four “healthy” preterm infants (31%) were identified. The “ill” infants were divided into four subgroups dependent on gestational age and small for gestational age. Reference levels for the growth parameters and metabolic biomarkers glucose, albumin, and adiponectin, and two glucose control indicators, glycated albumin and fructosamine, were determined for the “healthy” and “ill” subgroups. The “ill” extremely preterm infants had increased glucose levels (mean difference 0.71 mmol/L, 95% CI 0.23; 1.18 mmol/L) and glycated albumin (corrected; %) (mean difference 0.92 mmol/L, 95% CI 0.38 mmol/L;1.47 mmol/L) compared to the “healthy” infants. In “ill” extremely preterm infants and “ill” very preterm infants born small for gestational age, levels of biomarkers containing proteins were decreased. In the “Ill” extremely preterm infants and infants born small for gestational age, postnatal growth was continuously decreased throughout the postconceptional period. The short-term glucose-control indicator, glycated albumin (corrected; %), reflected well the high glucose levels due to its correction for the depleted plasma-protein pool. MDPI 2023-08-24 /pmc/articles/PMC10525969/ /pubmed/37760819 http://dx.doi.org/10.3390/biomedicines11092377 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bjerager, Mia O.
Hansen, Bo M.
Sørensen, Frederik
Petersen, Jes R.
Jensen, Kristian V.
Hjelvang, Brian R.
Hvelplund, Anna C.
Olsen, Dorte A.
Nielsen, Aneta A.
Forman, Julie L.
Brandslund, Ivan
Greisen, Gorm
Slidsborg, Carina
Blood-Biomarkers for Glucose Metabolism in Preterm Infants
title Blood-Biomarkers for Glucose Metabolism in Preterm Infants
title_full Blood-Biomarkers for Glucose Metabolism in Preterm Infants
title_fullStr Blood-Biomarkers for Glucose Metabolism in Preterm Infants
title_full_unstemmed Blood-Biomarkers for Glucose Metabolism in Preterm Infants
title_short Blood-Biomarkers for Glucose Metabolism in Preterm Infants
title_sort blood-biomarkers for glucose metabolism in preterm infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525969/
https://www.ncbi.nlm.nih.gov/pubmed/37760819
http://dx.doi.org/10.3390/biomedicines11092377
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