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Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics
Tuberculosis meningitis (TBM) is a result of the invasion of the meninges with the bacilli of Mycobacterium tuberculosis (Mtb), leading to inflammation of the meninges around the brain or spinal cord. Oxidative stress occurs when the body’s cells become overwhelmed with free radicals, particularly r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526095/ https://www.ncbi.nlm.nih.gov/pubmed/37761009 http://dx.doi.org/10.3390/biomedicines11092568 |
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author | Navasardyan, Inesa Yeganyan, Stephanie Nguyen, Helena Vaghashia, Payal Subbian, Selvakumar Venketaraman, Vishwanath |
author_facet | Navasardyan, Inesa Yeganyan, Stephanie Nguyen, Helena Vaghashia, Payal Subbian, Selvakumar Venketaraman, Vishwanath |
author_sort | Navasardyan, Inesa |
collection | PubMed |
description | Tuberculosis meningitis (TBM) is a result of the invasion of the meninges with the bacilli of Mycobacterium tuberculosis (Mtb), leading to inflammation of the meninges around the brain or spinal cord. Oxidative stress occurs when the body’s cells become overwhelmed with free radicals, particularly reactive oxygen species (ROS). ROS plays a significant role in the pathogenesis of TBM due to their toxic nature, resulting in impairment of the body’s ability to fight off infection. ROS damages the endothelial cells and impairs the defense mechanisms of the blood–brain barrier (BBB), which contributes to CNS susceptibility to the bacteria causing TBM. Diabetes mellitus (DM) is a common condition that is characterized by the impairment of the hormone insulin, which is responsible for modulating blood glucose levels. The increased availability of glucose in individuals with diabetes results in increased cellular activity and metabolism, leading to heightened ROS production and, in turn, increased susceptibility to TBM. In this review, we summarize our current understanding of oxidative stress and its role in both TBM and DM. We further discuss how increased oxidative stress in DM can contribute to the likelihood of developing TBM and potential therapeutic approaches that may be of therapeutic value. |
format | Online Article Text |
id | pubmed-10526095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105260952023-09-28 Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics Navasardyan, Inesa Yeganyan, Stephanie Nguyen, Helena Vaghashia, Payal Subbian, Selvakumar Venketaraman, Vishwanath Biomedicines Review Tuberculosis meningitis (TBM) is a result of the invasion of the meninges with the bacilli of Mycobacterium tuberculosis (Mtb), leading to inflammation of the meninges around the brain or spinal cord. Oxidative stress occurs when the body’s cells become overwhelmed with free radicals, particularly reactive oxygen species (ROS). ROS plays a significant role in the pathogenesis of TBM due to their toxic nature, resulting in impairment of the body’s ability to fight off infection. ROS damages the endothelial cells and impairs the defense mechanisms of the blood–brain barrier (BBB), which contributes to CNS susceptibility to the bacteria causing TBM. Diabetes mellitus (DM) is a common condition that is characterized by the impairment of the hormone insulin, which is responsible for modulating blood glucose levels. The increased availability of glucose in individuals with diabetes results in increased cellular activity and metabolism, leading to heightened ROS production and, in turn, increased susceptibility to TBM. In this review, we summarize our current understanding of oxidative stress and its role in both TBM and DM. We further discuss how increased oxidative stress in DM can contribute to the likelihood of developing TBM and potential therapeutic approaches that may be of therapeutic value. MDPI 2023-09-19 /pmc/articles/PMC10526095/ /pubmed/37761009 http://dx.doi.org/10.3390/biomedicines11092568 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Navasardyan, Inesa Yeganyan, Stephanie Nguyen, Helena Vaghashia, Payal Subbian, Selvakumar Venketaraman, Vishwanath Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics |
title | Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics |
title_full | Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics |
title_fullStr | Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics |
title_full_unstemmed | Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics |
title_short | Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics |
title_sort | role of oxidative stress in tuberculosis meningitis infection in diabetics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526095/ https://www.ncbi.nlm.nih.gov/pubmed/37761009 http://dx.doi.org/10.3390/biomedicines11092568 |
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