Cargando…

Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics

Tuberculosis meningitis (TBM) is a result of the invasion of the meninges with the bacilli of Mycobacterium tuberculosis (Mtb), leading to inflammation of the meninges around the brain or spinal cord. Oxidative stress occurs when the body’s cells become overwhelmed with free radicals, particularly r...

Descripción completa

Detalles Bibliográficos
Autores principales: Navasardyan, Inesa, Yeganyan, Stephanie, Nguyen, Helena, Vaghashia, Payal, Subbian, Selvakumar, Venketaraman, Vishwanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526095/
https://www.ncbi.nlm.nih.gov/pubmed/37761009
http://dx.doi.org/10.3390/biomedicines11092568
_version_ 1785110941006823424
author Navasardyan, Inesa
Yeganyan, Stephanie
Nguyen, Helena
Vaghashia, Payal
Subbian, Selvakumar
Venketaraman, Vishwanath
author_facet Navasardyan, Inesa
Yeganyan, Stephanie
Nguyen, Helena
Vaghashia, Payal
Subbian, Selvakumar
Venketaraman, Vishwanath
author_sort Navasardyan, Inesa
collection PubMed
description Tuberculosis meningitis (TBM) is a result of the invasion of the meninges with the bacilli of Mycobacterium tuberculosis (Mtb), leading to inflammation of the meninges around the brain or spinal cord. Oxidative stress occurs when the body’s cells become overwhelmed with free radicals, particularly reactive oxygen species (ROS). ROS plays a significant role in the pathogenesis of TBM due to their toxic nature, resulting in impairment of the body’s ability to fight off infection. ROS damages the endothelial cells and impairs the defense mechanisms of the blood–brain barrier (BBB), which contributes to CNS susceptibility to the bacteria causing TBM. Diabetes mellitus (DM) is a common condition that is characterized by the impairment of the hormone insulin, which is responsible for modulating blood glucose levels. The increased availability of glucose in individuals with diabetes results in increased cellular activity and metabolism, leading to heightened ROS production and, in turn, increased susceptibility to TBM. In this review, we summarize our current understanding of oxidative stress and its role in both TBM and DM. We further discuss how increased oxidative stress in DM can contribute to the likelihood of developing TBM and potential therapeutic approaches that may be of therapeutic value.
format Online
Article
Text
id pubmed-10526095
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105260952023-09-28 Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics Navasardyan, Inesa Yeganyan, Stephanie Nguyen, Helena Vaghashia, Payal Subbian, Selvakumar Venketaraman, Vishwanath Biomedicines Review Tuberculosis meningitis (TBM) is a result of the invasion of the meninges with the bacilli of Mycobacterium tuberculosis (Mtb), leading to inflammation of the meninges around the brain or spinal cord. Oxidative stress occurs when the body’s cells become overwhelmed with free radicals, particularly reactive oxygen species (ROS). ROS plays a significant role in the pathogenesis of TBM due to their toxic nature, resulting in impairment of the body’s ability to fight off infection. ROS damages the endothelial cells and impairs the defense mechanisms of the blood–brain barrier (BBB), which contributes to CNS susceptibility to the bacteria causing TBM. Diabetes mellitus (DM) is a common condition that is characterized by the impairment of the hormone insulin, which is responsible for modulating blood glucose levels. The increased availability of glucose in individuals with diabetes results in increased cellular activity and metabolism, leading to heightened ROS production and, in turn, increased susceptibility to TBM. In this review, we summarize our current understanding of oxidative stress and its role in both TBM and DM. We further discuss how increased oxidative stress in DM can contribute to the likelihood of developing TBM and potential therapeutic approaches that may be of therapeutic value. MDPI 2023-09-19 /pmc/articles/PMC10526095/ /pubmed/37761009 http://dx.doi.org/10.3390/biomedicines11092568 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Navasardyan, Inesa
Yeganyan, Stephanie
Nguyen, Helena
Vaghashia, Payal
Subbian, Selvakumar
Venketaraman, Vishwanath
Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics
title Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics
title_full Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics
title_fullStr Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics
title_full_unstemmed Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics
title_short Role of Oxidative Stress in Tuberculosis Meningitis Infection in Diabetics
title_sort role of oxidative stress in tuberculosis meningitis infection in diabetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526095/
https://www.ncbi.nlm.nih.gov/pubmed/37761009
http://dx.doi.org/10.3390/biomedicines11092568
work_keys_str_mv AT navasardyaninesa roleofoxidativestressintuberculosismeningitisinfectionindiabetics
AT yeganyanstephanie roleofoxidativestressintuberculosismeningitisinfectionindiabetics
AT nguyenhelena roleofoxidativestressintuberculosismeningitisinfectionindiabetics
AT vaghashiapayal roleofoxidativestressintuberculosismeningitisinfectionindiabetics
AT subbianselvakumar roleofoxidativestressintuberculosismeningitisinfectionindiabetics
AT venketaramanvishwanath roleofoxidativestressintuberculosismeningitisinfectionindiabetics