Cargando…

Abscisic Acid and Its Receptors LANCL1 and LANCL2 Control Cardiomyocyte Mitochondrial Function, Expression of Contractile, Cytoskeletal and Ion Channel Proteins and Cell Proliferation via ERRα

The cross-kingdom stress hormone abscisic acid (ABA) and its mammalian receptors LANCL1 and LANCL2 regulate the response of cardiomyocytes to hypoxia by activating NO generation. The overexpression of LANCL1/2 increases transcription, phosphorylation and the activity of eNOS and improves cell vitali...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spinelli, Sonia, Guida, Lucrezia, Passalacqua, Mario, Magnone, Mirko, Cossu, Vanessa, Sambuceti, Gianmario, Marini, Cecilia, Sturla, Laura, Zocchi, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526111/ https://www.ncbi.nlm.nih.gov/pubmed/37759995 http://dx.doi.org/10.3390/antiox12091692

Ejemplares similares

The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure
por: Spinelli, Sonia, et al.
Publicado: (2023)

The ABA/LANCL Hormone/Receptor System in the Control of Glycemia, of Cardiomyocyte Energy Metabolism, and in Neuroprotection: A New Ally in the Treatment of Diabetes Mellitus?
por: Spinelli, Sonia, et al.
Publicado: (2023)

G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2
por: Fresia, Chiara, et al.
Publicado: (2016)

LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway
por: Spinelli, Sonia, et al.
Publicado: (2021)

The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism
por: Spinelli, Sonia, et al.
Publicado: (2022)

Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation
por: Magnone, Mirko, et al.
Publicado: (2020)

Abscisic Acid Improves Insulin Action on Glycemia in Insulin-Deficient Mouse Models of Type 1 Diabetes
por: Magnone, Mirko, et al.
Publicado: (2022)

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals
por: He, Chang, et al.
Publicado: (2017)

33886 Deregulation of the LANCL2 Pathway in Alzheimer's Disease
por: Birnbaumria, Emily, et al.
Publicado: (2021)

LANCL1 as the Key Immune Marker in Neuropathic Pain
por: Shi, Yu, et al.
Publicado: (2022)

Abscisic Acid: A Conserved Hormone in Plants and Humans and a Promising Aid to Combat Prediabetes and the Metabolic Syndrome
por: Magnone, Mirko, et al.
Publicado: (2020)

Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle
por: Leber, Andrew, et al.
Publicado: (2020)

Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord
por: Maixner, Dylan W, et al.
Publicado: (2022)

Identification of Critical Pathways and Hub Genes in LanCL1-Overexpressed Prostate Cancer Cells
por: Tang, Run, et al.
Publicado: (2020)

Single-Cell RNAseq Resolve the Potential Effects of LanCL1 Gene in the Mouse Testis
por: Lu, Jiangting, et al.
Publicado: (2022)

Lanthionine synthetase C–like protein 2 (LanCL2) is a novel regulator of Akt
por: Zeng, Min, et al.
Publicado: (2014)

LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice
por: Tan, Honglin, et al.
Publicado: (2019)

Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis
por: Lou, Yuqing, et al.
Publicado: (2021)

LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway
por: Wang, Jianqing, et al.
Publicado: (2018)

Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection
por: Leber, Andrew, et al.
Publicado: (2016)

The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice
por: Zhang, Fangxing, et al.
Publicado: (2020)

First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis
por: Tubau-Juni, Nuria, et al.
Publicado: (2021)

Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice
por: Magnone, Mirko, et al.
Publicado: (2018)

Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients
por: Zhao, Hua-fu, et al.
Publicado: (2021)

Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
por: Pan, Hui, et al.
Publicado: (2023)

Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats
por: Bruzzone, Santina, et al.
Publicado: (2015)

The role of endoplasmic reticulum in in vivo cancer FDG kinetics
por: Sommariva, Sara, et al.
Publicado: (2021)

Abscisic Acid: A Novel Nutraceutical for Glycemic Control
por: Zocchi, Elena, et al.
Publicado: (2017)

The cytoskeletal and contractile apparatus of smooth muscle: contraction bands and segmentation of the contractile elements
Publicado: (1990)

Therapeutic efficacy of proton transport inhibitors alone or in combination with cisplatin in triple negative and hormone sensitive breast cancer models
por: Balza, Enrica, et al.
Publicado: (2021)

Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?
por: Marini, Cecilia, et al.
Publicado: (2021)

The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation
por: Sakamoto, Tomoya, et al.
Publicado: (2022)

Fractalkine Depresses Cardiomyocyte Contractility
por: Taube, David, et al.
Publicado: (2013)

Synthesis of cytoskeletal and contractile proteins by cultured IMR-90 fibroblasts
Publicado: (1985)

Reversal of contractility as a signature of self-organization in cytoskeletal bundles
por: Lenz, Martin
Publicado: (2020)

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
por: Miki, Kenji, et al.
Publicado: (2021)

Correction: Fractalkine Depresses Cardiomyocyte Contractility
por: Taube, David, et al.
Publicado: (2013)

Tidal Stretches Differently Regulate the Contractile and Cytoskeletal Elements in Intact Airways
por: Bartolák-Suki, Erzsébet, et al.
Publicado: (2014)

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy
por: Ross, Jacob A., et al.
Publicado: (2019)

Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting
por: Pastorino, Sara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0mj4dkirhhange1mcc4kbcqm0n