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Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma

SIMPLE SUMMARY: There have been a number of advances in the treatment paradigm of pancreatic ductal adenocarcinoma (PDAC) over the past two decades. Medical and surgical approaches to PDAC have continued to evolve. The individual effects of these changes have been investigated. Understanding the imp...

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Autores principales: Underwood, Patrick W., Herremans, Kelly M., Neal, Dan, Riner, Andrea N., Nassour, Ibrahim, Hughes, Steven J., Trevino, Jose G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526129/
https://www.ncbi.nlm.nih.gov/pubmed/37760433
http://dx.doi.org/10.3390/cancers15184464
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author Underwood, Patrick W.
Herremans, Kelly M.
Neal, Dan
Riner, Andrea N.
Nassour, Ibrahim
Hughes, Steven J.
Trevino, Jose G.
author_facet Underwood, Patrick W.
Herremans, Kelly M.
Neal, Dan
Riner, Andrea N.
Nassour, Ibrahim
Hughes, Steven J.
Trevino, Jose G.
author_sort Underwood, Patrick W.
collection PubMed
description SIMPLE SUMMARY: There have been a number of advances in the treatment paradigm of pancreatic ductal adenocarcinoma (PDAC) over the past two decades. Medical and surgical approaches to PDAC have continued to evolve. The individual effects of these changes have been investigated. Understanding the implementation of these changes over time and its effect on patient survival is important. While patient survival from PDAC has been reported to have modest improvements over the decades, the National Cancer Database offers the ability to study survival trends. We aim to evaluate survival trends in patients diagnosed with PDAC in the United States. ABSTRACT: Over the last two decades, there have been many reported advances in the clinical management of pancreatic ductal adenocarcinoma (PDAC). We sought to evaluate changes in survival for patients diagnosed with PDAC between 2004 and 2017. The National Cancer Database was queried for patients diagnosed with PDAC between 2004 and 2017. There were 55,401 patients who underwent surgery and 109,477 patients who underwent non-surgical treatment for PDAC between 2004 and 2017. Patients were categorized into four groups by year of diagnosis. Median survival improved from 15.5 months to 25.3 months for patients treated with surgery between the years 2016 and 2017 compared with between 2004 and 2007 (p < 0.001). Median survival improved from 7.2 months to 10.1 months for patients treated without surgery during the same years (p < 0.001). On multivariable analysis, the hazard ratio for death was estimated to multiply by 0.975 per year for patients treated with surgery and 0.959 per year for patients treated without surgery (p < 0.001). This increase in survival in the setting of evolving care validates continued efforts aimed at improving survival for patients with this devastating disease.
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spelling pubmed-105261292023-09-28 Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma Underwood, Patrick W. Herremans, Kelly M. Neal, Dan Riner, Andrea N. Nassour, Ibrahim Hughes, Steven J. Trevino, Jose G. Cancers (Basel) Article SIMPLE SUMMARY: There have been a number of advances in the treatment paradigm of pancreatic ductal adenocarcinoma (PDAC) over the past two decades. Medical and surgical approaches to PDAC have continued to evolve. The individual effects of these changes have been investigated. Understanding the implementation of these changes over time and its effect on patient survival is important. While patient survival from PDAC has been reported to have modest improvements over the decades, the National Cancer Database offers the ability to study survival trends. We aim to evaluate survival trends in patients diagnosed with PDAC in the United States. ABSTRACT: Over the last two decades, there have been many reported advances in the clinical management of pancreatic ductal adenocarcinoma (PDAC). We sought to evaluate changes in survival for patients diagnosed with PDAC between 2004 and 2017. The National Cancer Database was queried for patients diagnosed with PDAC between 2004 and 2017. There were 55,401 patients who underwent surgery and 109,477 patients who underwent non-surgical treatment for PDAC between 2004 and 2017. Patients were categorized into four groups by year of diagnosis. Median survival improved from 15.5 months to 25.3 months for patients treated with surgery between the years 2016 and 2017 compared with between 2004 and 2007 (p < 0.001). Median survival improved from 7.2 months to 10.1 months for patients treated without surgery during the same years (p < 0.001). On multivariable analysis, the hazard ratio for death was estimated to multiply by 0.975 per year for patients treated with surgery and 0.959 per year for patients treated without surgery (p < 0.001). This increase in survival in the setting of evolving care validates continued efforts aimed at improving survival for patients with this devastating disease. MDPI 2023-09-07 /pmc/articles/PMC10526129/ /pubmed/37760433 http://dx.doi.org/10.3390/cancers15184464 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Underwood, Patrick W.
Herremans, Kelly M.
Neal, Dan
Riner, Andrea N.
Nassour, Ibrahim
Hughes, Steven J.
Trevino, Jose G.
Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma
title Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma
title_full Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma
title_fullStr Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma
title_full_unstemmed Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma
title_short Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma
title_sort changing practice patterns and improving survival for patients with pancreatic ductal adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526129/
https://www.ncbi.nlm.nih.gov/pubmed/37760433
http://dx.doi.org/10.3390/cancers15184464
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