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Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms

The primary aim of this study was to determine the minimal clinically important difference (MCID) for the EuroQol-5D questionnaire (EQ-5D-5L) index and visual analogic scale (VAS) in individuals experiencing long-term post-COVID-19 symptoms. In addition, it was pretended to determine which variable...

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Autores principales: del Corral, Tamara, Fabero-Garrido, Raúl, Plaza-Manzano, Gustavo, Navarro-Santana, Marcos José, Fernández-de-las-Peñas, César, López-de-Uralde-Villanueva, Ibai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526144/
https://www.ncbi.nlm.nih.gov/pubmed/37760964
http://dx.doi.org/10.3390/biomedicines11092522
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author del Corral, Tamara
Fabero-Garrido, Raúl
Plaza-Manzano, Gustavo
Navarro-Santana, Marcos José
Fernández-de-las-Peñas, César
López-de-Uralde-Villanueva, Ibai
author_facet del Corral, Tamara
Fabero-Garrido, Raúl
Plaza-Manzano, Gustavo
Navarro-Santana, Marcos José
Fernández-de-las-Peñas, César
López-de-Uralde-Villanueva, Ibai
author_sort del Corral, Tamara
collection PubMed
description The primary aim of this study was to determine the minimal clinically important difference (MCID) for the EuroQol-5D questionnaire (EQ-5D-5L) index and visual analogic scale (VAS) in individuals experiencing long-term post-COVID-19 symptoms. In addition, it was pretended to determine which variable discriminates better and to compare changes between individuals classified by the MCID. Design: Secondary analysis of a randomized controlled trial involving 42 individuals who underwent an 8-week intervention in a respiratory muscle training program. Results: A change of at least 0.262 and 7.5 for the EQ-5D-5L index and VAS represented the MCID, respectively. Only the EQ-5D-5L VAS showed acceptable discrimination between individuals who were classified as “improved” and those classified as “stable/not improved” (area under the curve = 0.78), although with a low Youden index (Youden index, 0.39; sensitivity, 46.2%; specificity, 93.1%). Those individuals who exceeded the established MCID for EQ-5D-5L VAS had significantly greater improvements in inspiratory muscle function, exercise tolerance, and peripheral muscle strength compared to participants classified as “stable/not improved”. Conclusions: Only the EQ-5D-5L VAS, especially when MCID was exceeded, showed an acceptable discriminative ability to evaluate the efficacy of an intervention in individuals with long-term post-COVID-19 symptoms.
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spelling pubmed-105261442023-09-28 Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms del Corral, Tamara Fabero-Garrido, Raúl Plaza-Manzano, Gustavo Navarro-Santana, Marcos José Fernández-de-las-Peñas, César López-de-Uralde-Villanueva, Ibai Biomedicines Article The primary aim of this study was to determine the minimal clinically important difference (MCID) for the EuroQol-5D questionnaire (EQ-5D-5L) index and visual analogic scale (VAS) in individuals experiencing long-term post-COVID-19 symptoms. In addition, it was pretended to determine which variable discriminates better and to compare changes between individuals classified by the MCID. Design: Secondary analysis of a randomized controlled trial involving 42 individuals who underwent an 8-week intervention in a respiratory muscle training program. Results: A change of at least 0.262 and 7.5 for the EQ-5D-5L index and VAS represented the MCID, respectively. Only the EQ-5D-5L VAS showed acceptable discrimination between individuals who were classified as “improved” and those classified as “stable/not improved” (area under the curve = 0.78), although with a low Youden index (Youden index, 0.39; sensitivity, 46.2%; specificity, 93.1%). Those individuals who exceeded the established MCID for EQ-5D-5L VAS had significantly greater improvements in inspiratory muscle function, exercise tolerance, and peripheral muscle strength compared to participants classified as “stable/not improved”. Conclusions: Only the EQ-5D-5L VAS, especially when MCID was exceeded, showed an acceptable discriminative ability to evaluate the efficacy of an intervention in individuals with long-term post-COVID-19 symptoms. MDPI 2023-09-13 /pmc/articles/PMC10526144/ /pubmed/37760964 http://dx.doi.org/10.3390/biomedicines11092522 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
del Corral, Tamara
Fabero-Garrido, Raúl
Plaza-Manzano, Gustavo
Navarro-Santana, Marcos José
Fernández-de-las-Peñas, César
López-de-Uralde-Villanueva, Ibai
Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms
title Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms
title_full Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms
title_fullStr Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms
title_full_unstemmed Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms
title_short Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms
title_sort minimal clinically important differences in eq-5d-5l index and vas after a respiratory muscle training program in individuals experiencing long-term post-covid-19 symptoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526144/
https://www.ncbi.nlm.nih.gov/pubmed/37760964
http://dx.doi.org/10.3390/biomedicines11092522
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