Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70(−/−) Mice with a Human-like Bile Acid Composition

Bile acids (BAs) and their signaling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated Cyp2c70(−/−) (KO) mice that were not able to convert chenodeoxycholic acid into rodent-specific muricholic acids (MCAs) and, hence, possessed a more hydrophobic, h...

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Detalles Bibliográficos
Autores principales: Palmiotti, Anna, de Vries, Hilde D., Hovingh, Milaine V., Koehorst, Martijn, Mulder, Niels L., Verkade, Esther, Veentjer, Melany K., van Dijk, Theo H., Bloks, Vincent W., Havinga, Rick, Verkade, Henkjan J., de Boer, Jan Freark, Kuipers, Folkert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526181/
https://www.ncbi.nlm.nih.gov/pubmed/37760936
http://dx.doi.org/10.3390/biomedicines11092495

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