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An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman

Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) acco...

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Autores principales: Al-Ruhaili, Intisar, Al-Huseini, Salim, Al-Kaabi, Said, Mahadevan, Sangeetha, Al-Sibani, Nasser, Al Balushi, Naser, Islam, M. Mazharul, Jose, Sachin, Mehr, Gilda Kiani, Al-Adawi, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526207/
https://www.ncbi.nlm.nih.gov/pubmed/37759890
http://dx.doi.org/10.3390/brainsci13091289
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author Al-Ruhaili, Intisar
Al-Huseini, Salim
Al-Kaabi, Said
Mahadevan, Sangeetha
Al-Sibani, Nasser
Al Balushi, Naser
Islam, M. Mazharul
Jose, Sachin
Mehr, Gilda Kiani
Al-Adawi, Samir
author_facet Al-Ruhaili, Intisar
Al-Huseini, Salim
Al-Kaabi, Said
Mahadevan, Sangeetha
Al-Sibani, Nasser
Al Balushi, Naser
Islam, M. Mazharul
Jose, Sachin
Mehr, Gilda Kiani
Al-Adawi, Samir
author_sort Al-Ruhaili, Intisar
collection PubMed
description Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) accompanied by physical symptoms. Data were obtained from a prospective study conducted among patients with TRD and some somatic manifestations who underwent 20 sessions of rTMS intervention from January to June 2020. The Hamilton Rating Scale for Depression (HAMD) was used for clinical evaluation. Data were analysed using descriptive and inferential techniques (multiple logistic regression) in SPSS. Among the 49 participants (mean age: 42.5 ± 13.3), there was a significant reduction in posttreatment HAMD scores compared to baseline (t = 10.819, p < 0.0001, and 95% CI = 8.574–12.488), indicating a clinical response. Approximately 37% of the patients responded to treatment, with higher response rates among men and those who remained in urban areas, had a history of alcohol use, and were subjected to the standard 10 HZ protocol. After adjusting for all extraneous variables, the rTMS protocol emerged as the only significant predictor of response to the rTMS intervention. To our knowledge, this is the first study to examine the effectiveness of rTMS in the treatment of somatic depression.
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spelling pubmed-105262072023-09-28 An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman Al-Ruhaili, Intisar Al-Huseini, Salim Al-Kaabi, Said Mahadevan, Sangeetha Al-Sibani, Nasser Al Balushi, Naser Islam, M. Mazharul Jose, Sachin Mehr, Gilda Kiani Al-Adawi, Samir Brain Sci Article Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) accompanied by physical symptoms. Data were obtained from a prospective study conducted among patients with TRD and some somatic manifestations who underwent 20 sessions of rTMS intervention from January to June 2020. The Hamilton Rating Scale for Depression (HAMD) was used for clinical evaluation. Data were analysed using descriptive and inferential techniques (multiple logistic regression) in SPSS. Among the 49 participants (mean age: 42.5 ± 13.3), there was a significant reduction in posttreatment HAMD scores compared to baseline (t = 10.819, p < 0.0001, and 95% CI = 8.574–12.488), indicating a clinical response. Approximately 37% of the patients responded to treatment, with higher response rates among men and those who remained in urban areas, had a history of alcohol use, and were subjected to the standard 10 HZ protocol. After adjusting for all extraneous variables, the rTMS protocol emerged as the only significant predictor of response to the rTMS intervention. To our knowledge, this is the first study to examine the effectiveness of rTMS in the treatment of somatic depression. MDPI 2023-09-06 /pmc/articles/PMC10526207/ /pubmed/37759890 http://dx.doi.org/10.3390/brainsci13091289 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Ruhaili, Intisar
Al-Huseini, Salim
Al-Kaabi, Said
Mahadevan, Sangeetha
Al-Sibani, Nasser
Al Balushi, Naser
Islam, M. Mazharul
Jose, Sachin
Mehr, Gilda Kiani
Al-Adawi, Samir
An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman
title An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman
title_full An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman
title_fullStr An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman
title_full_unstemmed An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman
title_short An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman
title_sort evaluation of the effectiveness of repetitive transcranial magnetic stimulation (rtms) for the management of treatment-resistant depression with somatic attributes: a hospital-based study in oman
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526207/
https://www.ncbi.nlm.nih.gov/pubmed/37759890
http://dx.doi.org/10.3390/brainsci13091289
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