Cargando…
An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman
Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) acco...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526207/ https://www.ncbi.nlm.nih.gov/pubmed/37759890 http://dx.doi.org/10.3390/brainsci13091289 |
_version_ | 1785110966948593664 |
---|---|
author | Al-Ruhaili, Intisar Al-Huseini, Salim Al-Kaabi, Said Mahadevan, Sangeetha Al-Sibani, Nasser Al Balushi, Naser Islam, M. Mazharul Jose, Sachin Mehr, Gilda Kiani Al-Adawi, Samir |
author_facet | Al-Ruhaili, Intisar Al-Huseini, Salim Al-Kaabi, Said Mahadevan, Sangeetha Al-Sibani, Nasser Al Balushi, Naser Islam, M. Mazharul Jose, Sachin Mehr, Gilda Kiani Al-Adawi, Samir |
author_sort | Al-Ruhaili, Intisar |
collection | PubMed |
description | Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) accompanied by physical symptoms. Data were obtained from a prospective study conducted among patients with TRD and some somatic manifestations who underwent 20 sessions of rTMS intervention from January to June 2020. The Hamilton Rating Scale for Depression (HAMD) was used for clinical evaluation. Data were analysed using descriptive and inferential techniques (multiple logistic regression) in SPSS. Among the 49 participants (mean age: 42.5 ± 13.3), there was a significant reduction in posttreatment HAMD scores compared to baseline (t = 10.819, p < 0.0001, and 95% CI = 8.574–12.488), indicating a clinical response. Approximately 37% of the patients responded to treatment, with higher response rates among men and those who remained in urban areas, had a history of alcohol use, and were subjected to the standard 10 HZ protocol. After adjusting for all extraneous variables, the rTMS protocol emerged as the only significant predictor of response to the rTMS intervention. To our knowledge, this is the first study to examine the effectiveness of rTMS in the treatment of somatic depression. |
format | Online Article Text |
id | pubmed-10526207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105262072023-09-28 An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman Al-Ruhaili, Intisar Al-Huseini, Salim Al-Kaabi, Said Mahadevan, Sangeetha Al-Sibani, Nasser Al Balushi, Naser Islam, M. Mazharul Jose, Sachin Mehr, Gilda Kiani Al-Adawi, Samir Brain Sci Article Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) accompanied by physical symptoms. Data were obtained from a prospective study conducted among patients with TRD and some somatic manifestations who underwent 20 sessions of rTMS intervention from January to June 2020. The Hamilton Rating Scale for Depression (HAMD) was used for clinical evaluation. Data were analysed using descriptive and inferential techniques (multiple logistic regression) in SPSS. Among the 49 participants (mean age: 42.5 ± 13.3), there was a significant reduction in posttreatment HAMD scores compared to baseline (t = 10.819, p < 0.0001, and 95% CI = 8.574–12.488), indicating a clinical response. Approximately 37% of the patients responded to treatment, with higher response rates among men and those who remained in urban areas, had a history of alcohol use, and were subjected to the standard 10 HZ protocol. After adjusting for all extraneous variables, the rTMS protocol emerged as the only significant predictor of response to the rTMS intervention. To our knowledge, this is the first study to examine the effectiveness of rTMS in the treatment of somatic depression. MDPI 2023-09-06 /pmc/articles/PMC10526207/ /pubmed/37759890 http://dx.doi.org/10.3390/brainsci13091289 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Al-Ruhaili, Intisar Al-Huseini, Salim Al-Kaabi, Said Mahadevan, Sangeetha Al-Sibani, Nasser Al Balushi, Naser Islam, M. Mazharul Jose, Sachin Mehr, Gilda Kiani Al-Adawi, Samir An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman |
title | An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman |
title_full | An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman |
title_fullStr | An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman |
title_full_unstemmed | An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman |
title_short | An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman |
title_sort | evaluation of the effectiveness of repetitive transcranial magnetic stimulation (rtms) for the management of treatment-resistant depression with somatic attributes: a hospital-based study in oman |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526207/ https://www.ncbi.nlm.nih.gov/pubmed/37759890 http://dx.doi.org/10.3390/brainsci13091289 |
work_keys_str_mv | AT alruhailiintisar anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT alhuseinisalim anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT alkaabisaid anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT mahadevansangeetha anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT alsibaninasser anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT albalushinaser anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT islammmazharul anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT josesachin anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT mehrgildakiani anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT aladawisamir anevaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT alruhailiintisar evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT alhuseinisalim evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT alkaabisaid evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT mahadevansangeetha evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT alsibaninasser evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT albalushinaser evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT islammmazharul evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT josesachin evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT mehrgildakiani evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman AT aladawisamir evaluationoftheeffectivenessofrepetitivetranscranialmagneticstimulationrtmsforthemanagementoftreatmentresistantdepressionwithsomaticattributesahospitalbasedstudyinoman |