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Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy

SIMPLE SUMMARY: Cancer therapy in the older adult remains a challenge; much is unknown about treatment tolerance and impact on survival in this age group. Factors predicting serious toxicity and early death (ED) were identified in a series of 234 older adult patients treated with chemotherapy. Two s...

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Autores principales: Feliu, Jaime, Custodio, Ana Belén, Pinto-Marín, Alvaro, Higuera, Oliver, Pérez-González, Miriam, del Pino, Laura, Ruiz-Jiménez, Leticia, Sánchez-Cabero, Darío, Viera, Isabel, Jurado, Ana, Espinosa, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526243/
https://www.ncbi.nlm.nih.gov/pubmed/37760638
http://dx.doi.org/10.3390/cancers15184670
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author Feliu, Jaime
Custodio, Ana Belén
Pinto-Marín, Alvaro
Higuera, Oliver
Pérez-González, Miriam
del Pino, Laura
Ruiz-Jiménez, Leticia
Sánchez-Cabero, Darío
Viera, Isabel
Jurado, Ana
Espinosa, Enrique
author_facet Feliu, Jaime
Custodio, Ana Belén
Pinto-Marín, Alvaro
Higuera, Oliver
Pérez-González, Miriam
del Pino, Laura
Ruiz-Jiménez, Leticia
Sánchez-Cabero, Darío
Viera, Isabel
Jurado, Ana
Espinosa, Enrique
author_sort Feliu, Jaime
collection PubMed
description SIMPLE SUMMARY: Cancer therapy in the older adult remains a challenge; much is unknown about treatment tolerance and impact on survival in this age group. Factors predicting serious toxicity and early death (ED) were identified in a series of 234 older adult patients treated with chemotherapy. Two simple and reliable scores based on these factors were developed to predict the risk of grade 3–5 toxicity and ED, which can help in treatment planning and the implementation of corrective measures. ABSTRACT: Background: Determining the risk of grade 3–5 toxicity and early death (ED) is important to plan chemotherapy in older adult patients with cancer. Our objective was to identify factors predicting these complications at the time of treatment initiation. Methods: 234 patients aged ≥70 were subjected to a geriatric assessment and variables related to the tumor and the treatment were also collected. Logistic regression multivariable analysis was used to relate these factors with the appearance of grade 3–5 toxicity and ED. Predictive scores for both toxicity and ED were then developed. Results: Factors related to grade 3–5 toxicity were hemoglobin, MAX2 index, ADL, and the CONUT score. Factors related to ED were tumor stage and the GNRI score. Two predictive scores were developed using these variables. ROC curves for the prediction of toxicity and ED were 0.71 (95% CI: 0.64–0.78) and 0.73 (95% CI: 0.68–0.79), respectively. Conclusions: Two simple and reliable scores were developed to predict grade 3–5 toxicity and ED in older adult patients with cancer. This may be helpful in treatment planning.
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spelling pubmed-105262432023-09-28 Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy Feliu, Jaime Custodio, Ana Belén Pinto-Marín, Alvaro Higuera, Oliver Pérez-González, Miriam del Pino, Laura Ruiz-Jiménez, Leticia Sánchez-Cabero, Darío Viera, Isabel Jurado, Ana Espinosa, Enrique Cancers (Basel) Article SIMPLE SUMMARY: Cancer therapy in the older adult remains a challenge; much is unknown about treatment tolerance and impact on survival in this age group. Factors predicting serious toxicity and early death (ED) were identified in a series of 234 older adult patients treated with chemotherapy. Two simple and reliable scores based on these factors were developed to predict the risk of grade 3–5 toxicity and ED, which can help in treatment planning and the implementation of corrective measures. ABSTRACT: Background: Determining the risk of grade 3–5 toxicity and early death (ED) is important to plan chemotherapy in older adult patients with cancer. Our objective was to identify factors predicting these complications at the time of treatment initiation. Methods: 234 patients aged ≥70 were subjected to a geriatric assessment and variables related to the tumor and the treatment were also collected. Logistic regression multivariable analysis was used to relate these factors with the appearance of grade 3–5 toxicity and ED. Predictive scores for both toxicity and ED were then developed. Results: Factors related to grade 3–5 toxicity were hemoglobin, MAX2 index, ADL, and the CONUT score. Factors related to ED were tumor stage and the GNRI score. Two predictive scores were developed using these variables. ROC curves for the prediction of toxicity and ED were 0.71 (95% CI: 0.64–0.78) and 0.73 (95% CI: 0.68–0.79), respectively. Conclusions: Two simple and reliable scores were developed to predict grade 3–5 toxicity and ED in older adult patients with cancer. This may be helpful in treatment planning. MDPI 2023-09-21 /pmc/articles/PMC10526243/ /pubmed/37760638 http://dx.doi.org/10.3390/cancers15184670 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feliu, Jaime
Custodio, Ana Belén
Pinto-Marín, Alvaro
Higuera, Oliver
Pérez-González, Miriam
del Pino, Laura
Ruiz-Jiménez, Leticia
Sánchez-Cabero, Darío
Viera, Isabel
Jurado, Ana
Espinosa, Enrique
Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy
title Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy
title_full Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy
title_fullStr Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy
title_full_unstemmed Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy
title_short Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy
title_sort predicting risk of severe toxicity and early death in older adult patients treated with chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526243/
https://www.ncbi.nlm.nih.gov/pubmed/37760638
http://dx.doi.org/10.3390/cancers15184670
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