Cargando…

Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators

The proteasome, a complex multi-catalytic protease machinery, orchestrates the protein degradation essential for maintaining cellular homeostasis, and its dysregulation also underlies many different types of diseases. Its function is regulated by many different mechanisms that encompass various fact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Taylor, Salcedo-Tacuma, David, Smith, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526260/ https://www.ncbi.nlm.nih.gov/pubmed/37759726 http://dx.doi.org/10.3390/biom13091326

Ejemplares similares

Proteasome activator 28γ (PA28γ) allosterically activates trypsin-like proteolysis by binding to the α-ring of the 20S proteasome
por: Thomas, Taylor A., et al.
Publicado: (2022)

Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family
por: Deshmukh, Fanindra Kumar, et al.
Publicado: (2023)

Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
por: Haselbach, David, et al.
Publicado: (2017)

PA28αβ: The Enigmatic Magic Ring of the Proteasome?
por: Cascio, Paolo
Publicado: (2014)

Structural insights into the human PA28–20S proteasome enabled by efficient tagging and purification of endogenous proteins
por: Zhao, Jianhua, et al.
Publicado: (2022)

PA28γ: New Insights on an Ancient Proteasome Activator
por: Cascio, Paolo
Publicado: (2021)

Downregulation of PA28α induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma
por: Gu, Yanyan, et al.
Publicado: (2020)

Allosteric coupling between α-rings of the 20S proteasome
por: Yu, Zanlin, et al.
Publicado: (2020)

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
por: Lesne, Jean, et al.
Publicado: (2020)

Brain-Derived 11S Regulator (PA28αβ) Promotes Proteasomal Hydrolysis of Elongated Oligoglutamine-Containing Peptides
por: Kriachkov, Viacheslav A., et al.
Publicado: (2023)

The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function
por: Koçberber, Zeynep, et al.
Publicado: (2023)

Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility
por: Huang, Lin, et al.
Publicado: (2016)

Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy
por: Yadranji Aghdam, Saeed, et al.
Publicado: (2016)

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity
por: Adelöf, Julia, et al.
Publicado: (2018)

Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes
por: Toste Rêgo, Ana, et al.
Publicado: (2019)

Proteasome activator PA200 regulates myofibroblast differentiation
por: Welk, Vanessa, et al.
Publicado: (2019)

Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures
por: Guan, Hongxin, et al.
Publicado: (2020)

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ
por: Jonik-Nowak, Beata, et al.
Publicado: (2018)

Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
por: Chen, Jinhuan, et al.
Publicado: (2021)

Proteasome activator PA28γ regulates p53 by enhancing its MDM2-mediated degradation
por: Zhang, Zhuo, et al.
Publicado: (2008)

The Proteasome Activator PA28γ, a Negative Regulator of p53, Is Transcriptionally Up-Regulated by p53
por: Wan, Zhen-Xing, et al.
Publicado: (2014)

Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28
por: Hernebring, Malin, et al.
Publicado: (2013)

Increased proteasome activator 28 gamma (PA28γ) levels are unspecific but correlate with disease activity in rheumatoid arthritis
por: Gruner, Melanie, et al.
Publicado: (2014)

The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin
por: Aladdin, Azzam, et al.
Publicado: (2020)

ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function
por: Kim, Young-Chan, et al.
Publicado: (2015)

Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or Pa28
por: van Hall, Thorbald, et al.
Publicado: (2000)

Proteasome activator PA28γ-dependent degradation of coronavirus disease (COVID-19) nucleocapsid protein
por: Zhang, Haiyang, et al.
Publicado: (2020)

Modelling Proteasome and Proteasome Regulator Activities
por: Liepe, Juliane, et al.
Publicado: (2014)

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes
por: Lee, Hyun Ju, et al.
Publicado: (2023)

The Contribution of the 20S Proteasome to Proteostasis
por: Kumar Deshmukh, Fanindra, et al.
Publicado: (2019)

Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma
por: Feng, Xiaodong, et al.
Publicado: (2016)

Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure()
por: Pitcher, David S., et al.
Publicado: (2015)

Structural Insights into Substrate Recognition and Processing by the 20S Proteasome
por: Sahu, Indrajit, et al.
Publicado: (2021)

2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy
por: Campbell, Melody G, et al.
Publicado: (2015)

Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway
por: Ben-Nissan, Gili, et al.
Publicado: (2014)

Spatial Organization of Proteasome Aggregates in the Regulation of Proteasome Homeostasis
por: Karmon, Ofri, et al.
Publicado: (2020)

Ηigh-resolution structure of mammalian PI31–20S proteasome complex reveals mechanism of proteasome inhibition
por: Hsu, Hao-Chi, et al.
Publicado: (2023)

Proteins Directly Interacting with Mammalian 20S Proteasomal Subunits and Ubiquitin-Independent Proteasomal Degradation
por: Sánchez-Lanzas, Raúl, et al.
Publicado: (2014)

The mycobacterial proteasomal ATPase Mpa forms a gapped ring to engage the 20S proteasome
por: Yin, Yanting, et al.
Publicado: (2021)

Nostocyclopeptides as New Inhibitors of 20S Proteasome
por: Fidor, Anna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dtthks3hgoemu0ub7qc3m1d8vc