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GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation

The initiation of atherosclerotic plaque is characterized by endothelial cell inflammation. In light of gasdermin E’s (GSDME) role in pyroptosis and inflammation, this study elucidates its function in atherosclerosis onset. Employing Gsdme- and apolipoprotein E-deficient (Gsdme(−/−)/ApoE(−/−)) and A...

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Detalles Bibliográficos
Autores principales:	Xie, Shiyao, Su, Enyong, Song, Xiaoyue, Xue, Junqiang, Yu, Peng, Zhang, Baoli, Liu, Ming, Jiang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526370/ https://www.ncbi.nlm.nih.gov/pubmed/37761020 http://dx.doi.org/10.3390/biomedicines11092579

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