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Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential
Fungal alcohol dehydrogenases (ADHs) participate in growth under aerobic or anaerobic conditions, morphogenetic processes, and pathogenesis of diverse fungal genera. These processes are associated with metabolic operation routes related to alcohol, aldehyde, and acid production. The number of ADH en...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526403/ https://www.ncbi.nlm.nih.gov/pubmed/37759461 http://dx.doi.org/10.3390/cells12182239 |
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author | Gutiérrez-Corona, J. Félix González-Hernández, Gloria Angélica Padilla-Guerrero, Israel Enrique Olmedo-Monfil, Vianey Martínez-Rocha, Ana Lilia Patiño-Medina, J. Alberto Meza-Carmen, Víctor Torres-Guzmán, Juan Carlos |
author_facet | Gutiérrez-Corona, J. Félix González-Hernández, Gloria Angélica Padilla-Guerrero, Israel Enrique Olmedo-Monfil, Vianey Martínez-Rocha, Ana Lilia Patiño-Medina, J. Alberto Meza-Carmen, Víctor Torres-Guzmán, Juan Carlos |
author_sort | Gutiérrez-Corona, J. Félix |
collection | PubMed |
description | Fungal alcohol dehydrogenases (ADHs) participate in growth under aerobic or anaerobic conditions, morphogenetic processes, and pathogenesis of diverse fungal genera. These processes are associated with metabolic operation routes related to alcohol, aldehyde, and acid production. The number of ADH enzymes, their metabolic roles, and their functions vary within fungal species. The most studied ADHs are associated with ethanol metabolism, either as fermentative enzymes involved in the production of this alcohol or as oxidative enzymes necessary for the use of ethanol as a carbon source; other enzymes participate in survival under microaerobic conditions. The fast generation of data using genome sequencing provides an excellent opportunity to determine a correlation between the number of ADHs and fungal lifestyle. Therefore, this review aims to summarize the latest knowledge about the importance of ADH enzymes in the physiology and metabolism of fungal cells, as well as their structure, regulation, evolutionary relationships, and biotechnological potential. |
format | Online Article Text |
id | pubmed-10526403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105264032023-09-28 Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential Gutiérrez-Corona, J. Félix González-Hernández, Gloria Angélica Padilla-Guerrero, Israel Enrique Olmedo-Monfil, Vianey Martínez-Rocha, Ana Lilia Patiño-Medina, J. Alberto Meza-Carmen, Víctor Torres-Guzmán, Juan Carlos Cells Review Fungal alcohol dehydrogenases (ADHs) participate in growth under aerobic or anaerobic conditions, morphogenetic processes, and pathogenesis of diverse fungal genera. These processes are associated with metabolic operation routes related to alcohol, aldehyde, and acid production. The number of ADH enzymes, their metabolic roles, and their functions vary within fungal species. The most studied ADHs are associated with ethanol metabolism, either as fermentative enzymes involved in the production of this alcohol or as oxidative enzymes necessary for the use of ethanol as a carbon source; other enzymes participate in survival under microaerobic conditions. The fast generation of data using genome sequencing provides an excellent opportunity to determine a correlation between the number of ADHs and fungal lifestyle. Therefore, this review aims to summarize the latest knowledge about the importance of ADH enzymes in the physiology and metabolism of fungal cells, as well as their structure, regulation, evolutionary relationships, and biotechnological potential. MDPI 2023-09-08 /pmc/articles/PMC10526403/ /pubmed/37759461 http://dx.doi.org/10.3390/cells12182239 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gutiérrez-Corona, J. Félix González-Hernández, Gloria Angélica Padilla-Guerrero, Israel Enrique Olmedo-Monfil, Vianey Martínez-Rocha, Ana Lilia Patiño-Medina, J. Alberto Meza-Carmen, Víctor Torres-Guzmán, Juan Carlos Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential |
title | Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential |
title_full | Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential |
title_fullStr | Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential |
title_full_unstemmed | Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential |
title_short | Fungal Alcohol Dehydrogenases: Physiological Function, Molecular Properties, Regulation of Their Production, and Biotechnological Potential |
title_sort | fungal alcohol dehydrogenases: physiological function, molecular properties, regulation of their production, and biotechnological potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526403/ https://www.ncbi.nlm.nih.gov/pubmed/37759461 http://dx.doi.org/10.3390/cells12182239 |
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