Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model

SIMPLE SUMMARY: In colorectal cancer cells, reducing the essential amino acid methionine in the culture medium led to an increase in two markers of response to immune checkpoint inhibitors: MHC-I and PD-L1. The increase in MHC-I was associated with an increase in STING and type I interferon. The inc...

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Detalles Bibliográficos
Autores principales: Morehead, Lauren C., Garg, Sarita, Wallis, Katherine F., Simoes, Camila C., Siegel, Eric R., Tackett, Alan J., Miousse, Isabelle R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526448/
https://www.ncbi.nlm.nih.gov/pubmed/37760436
http://dx.doi.org/10.3390/cancers15184467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526448/
https://www.ncbi.nlm.nih.gov/pubmed/37760436
http://dx.doi.org/10.3390/cancers15184467

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