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New High-Affinity Thrombin Aptamers for Advancing Coagulation Therapy: Balancing Thrombin Inhibition for Clot Prevention and Effective Bleeding Management with Antidote

Thrombin is a key enzyme involved in blood clotting, and its dysregulation can lead to thrombotic diseases such as stroke, myocardial infarction, and deep vein thrombosis. Thrombin aptamers have the potential to be used as therapeutic agents to prevent or treat thrombotic diseases. Thrombin DNA apta...

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Detalles Bibliográficos
Autores principales:	Ayass, Mohamad Ammar, Griko, Natalya, Pashkov, Victor, Tripathi, Trivendra, Zhang, Jin, Ramankutty Nair, Ramya, Okyay, Tutku, Zhu, Kevin, Abi-Mosleh, Lina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526462/ https://www.ncbi.nlm.nih.gov/pubmed/37759453 http://dx.doi.org/10.3390/cells12182230

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