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Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life

The eyes provide themselves with immune tolerance. Frequent skin inflammatory diseases in young blind people suggest, nonetheless, that the eyes instruct a systemic immune tolerance that benefits the whole body. We tested this premise by using delayed skin contact hypersensitivity (DSCH) as a tool t...

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Autores principales: Villafán, Horacio, Gutiérrez-Ospina, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526493/
https://www.ncbi.nlm.nih.gov/pubmed/37759864
http://dx.doi.org/10.3390/brainsci13091261
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author Villafán, Horacio
Gutiérrez-Ospina, Gabriel
author_facet Villafán, Horacio
Gutiérrez-Ospina, Gabriel
author_sort Villafán, Horacio
collection PubMed
description The eyes provide themselves with immune tolerance. Frequent skin inflammatory diseases in young blind people suggest, nonetheless, that the eyes instruct a systemic immune tolerance that benefits the whole body. We tested this premise by using delayed skin contact hypersensitivity (DSCH) as a tool to compare the inflammatory response developed by sighted (S) and birth-enucleated (BE) mice against oxazolone or dinitrofluorobenzene at the ages of 10, 30 and 60 days of life. Adult mice enucleated (AE) at 60 days of age were also assessed when they reached 120 days of life. BE mice displayed exacerbated DSCH at 60 but not at 10 or 30 days of age. AE mice, in contrast, show no exacerbated DSCH. Skin inflammation in 60-day-old BE mice was hapten exclusive and supported by distinct CD8(+) lymphocytes. The number of intraepidermal T lymphocytes and migrating Langerhans cells was, however, similar between S and BE mice by the age of 60 days. Our observations support the idea that the eyes instruct systemic immune tolerance that benefits organs outside the eyes from an early age. The higher prevalence of inflammatory skin disorders reported in young people might then reflect reduced immune tolerance associated with the impaired functional morphology of the eyes.
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spelling pubmed-105264932023-09-28 Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life Villafán, Horacio Gutiérrez-Ospina, Gabriel Brain Sci Article The eyes provide themselves with immune tolerance. Frequent skin inflammatory diseases in young blind people suggest, nonetheless, that the eyes instruct a systemic immune tolerance that benefits the whole body. We tested this premise by using delayed skin contact hypersensitivity (DSCH) as a tool to compare the inflammatory response developed by sighted (S) and birth-enucleated (BE) mice against oxazolone or dinitrofluorobenzene at the ages of 10, 30 and 60 days of life. Adult mice enucleated (AE) at 60 days of age were also assessed when they reached 120 days of life. BE mice displayed exacerbated DSCH at 60 but not at 10 or 30 days of age. AE mice, in contrast, show no exacerbated DSCH. Skin inflammation in 60-day-old BE mice was hapten exclusive and supported by distinct CD8(+) lymphocytes. The number of intraepidermal T lymphocytes and migrating Langerhans cells was, however, similar between S and BE mice by the age of 60 days. Our observations support the idea that the eyes instruct systemic immune tolerance that benefits organs outside the eyes from an early age. The higher prevalence of inflammatory skin disorders reported in young people might then reflect reduced immune tolerance associated with the impaired functional morphology of the eyes. MDPI 2023-08-30 /pmc/articles/PMC10526493/ /pubmed/37759864 http://dx.doi.org/10.3390/brainsci13091261 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Villafán, Horacio
Gutiérrez-Ospina, Gabriel
Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life
title Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life
title_full Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life
title_fullStr Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life
title_full_unstemmed Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life
title_short Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life
title_sort looking beyond self-protection: the eyes instruct systemic immune tolerance early in life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526493/
https://www.ncbi.nlm.nih.gov/pubmed/37759864
http://dx.doi.org/10.3390/brainsci13091261
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