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Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence

Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have cont...

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Autores principales: He, Zhirong, Xu, Kun, Li, Yongming, Gao, Han, Miao, Tingting, Zhao, Rui, Huang, Yanyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526510/
https://www.ncbi.nlm.nih.gov/pubmed/37754071
http://dx.doi.org/10.3390/bios13090838
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author He, Zhirong
Xu, Kun
Li, Yongming
Gao, Han
Miao, Tingting
Zhao, Rui
Huang, Yanyan
author_facet He, Zhirong
Xu, Kun
Li, Yongming
Gao, Han
Miao, Tingting
Zhao, Rui
Huang, Yanyan
author_sort He, Zhirong
collection PubMed
description Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence. The molecular design, sensing mechanisms, and biological activities of the sensors are discussed. The sensors are categorized by the types of markers and targeting ligands. Accordingly, their molecular recognition and fluorescent performance towards senescence biomarkers are summarized. Finally, the perspective and challenges in this field are discussed, which are expected to assist future design of next-generation sensors for monitoring cellular senescence.
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spelling pubmed-105265102023-09-28 Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence He, Zhirong Xu, Kun Li, Yongming Gao, Han Miao, Tingting Zhao, Rui Huang, Yanyan Biosensors (Basel) Review Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence. The molecular design, sensing mechanisms, and biological activities of the sensors are discussed. The sensors are categorized by the types of markers and targeting ligands. Accordingly, their molecular recognition and fluorescent performance towards senescence biomarkers are summarized. Finally, the perspective and challenges in this field are discussed, which are expected to assist future design of next-generation sensors for monitoring cellular senescence. MDPI 2023-08-23 /pmc/articles/PMC10526510/ /pubmed/37754071 http://dx.doi.org/10.3390/bios13090838 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Zhirong
Xu, Kun
Li, Yongming
Gao, Han
Miao, Tingting
Zhao, Rui
Huang, Yanyan
Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
title Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
title_full Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
title_fullStr Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
title_full_unstemmed Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
title_short Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
title_sort molecularly targeted fluorescent sensors for visualizing and tracking cellular senescence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526510/
https://www.ncbi.nlm.nih.gov/pubmed/37754071
http://dx.doi.org/10.3390/bios13090838
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