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Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have cont...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526510/ https://www.ncbi.nlm.nih.gov/pubmed/37754071 http://dx.doi.org/10.3390/bios13090838 |
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author | He, Zhirong Xu, Kun Li, Yongming Gao, Han Miao, Tingting Zhao, Rui Huang, Yanyan |
author_facet | He, Zhirong Xu, Kun Li, Yongming Gao, Han Miao, Tingting Zhao, Rui Huang, Yanyan |
author_sort | He, Zhirong |
collection | PubMed |
description | Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence. The molecular design, sensing mechanisms, and biological activities of the sensors are discussed. The sensors are categorized by the types of markers and targeting ligands. Accordingly, their molecular recognition and fluorescent performance towards senescence biomarkers are summarized. Finally, the perspective and challenges in this field are discussed, which are expected to assist future design of next-generation sensors for monitoring cellular senescence. |
format | Online Article Text |
id | pubmed-10526510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105265102023-09-28 Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence He, Zhirong Xu, Kun Li, Yongming Gao, Han Miao, Tingting Zhao, Rui Huang, Yanyan Biosensors (Basel) Review Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence. The molecular design, sensing mechanisms, and biological activities of the sensors are discussed. The sensors are categorized by the types of markers and targeting ligands. Accordingly, their molecular recognition and fluorescent performance towards senescence biomarkers are summarized. Finally, the perspective and challenges in this field are discussed, which are expected to assist future design of next-generation sensors for monitoring cellular senescence. MDPI 2023-08-23 /pmc/articles/PMC10526510/ /pubmed/37754071 http://dx.doi.org/10.3390/bios13090838 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review He, Zhirong Xu, Kun Li, Yongming Gao, Han Miao, Tingting Zhao, Rui Huang, Yanyan Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
title | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
title_full | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
title_fullStr | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
title_full_unstemmed | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
title_short | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
title_sort | molecularly targeted fluorescent sensors for visualizing and tracking cellular senescence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526510/ https://www.ncbi.nlm.nih.gov/pubmed/37754071 http://dx.doi.org/10.3390/bios13090838 |
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