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Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury

Osteoporosis is a common skeletal disorder which can severely limit one’s ability to complete daily tasks due to the increased risk of bone fractures, reducing quality of life. Spinal cord injury (SCI) can also result in osteoporosis and sarcopenia. Most individuals experience sarcopenia and osteopo...

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Autores principales: Leone, Giovanna E., Shields, Donald C., Haque, Azizul, Banik, Narendra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526516/
https://www.ncbi.nlm.nih.gov/pubmed/37761022
http://dx.doi.org/10.3390/biomedicines11092581
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author Leone, Giovanna E.
Shields, Donald C.
Haque, Azizul
Banik, Narendra L.
author_facet Leone, Giovanna E.
Shields, Donald C.
Haque, Azizul
Banik, Narendra L.
author_sort Leone, Giovanna E.
collection PubMed
description Osteoporosis is a common skeletal disorder which can severely limit one’s ability to complete daily tasks due to the increased risk of bone fractures, reducing quality of life. Spinal cord injury (SCI) can also result in osteoporosis and sarcopenia. Most individuals experience sarcopenia and osteoporosis due to advancing age; however, individuals with SCI experience more rapid and debilitating levels of muscle and bone loss due to neurogenic factors, musculoskeletal disuse, and cellular/molecular events. Thus, preserving and maintaining bone mass after SCI is crucial to decreasing the risk of fragility and fracture in vulnerable SCI populations. Recent studies have provided an improved understanding of the pathophysiology and risk factors related to musculoskeletal loss after SCI. Pharmacological and non-pharmacological therapies have also provided for the reduction in or elimination of neurogenic bone loss after SCI. This review article will discuss the pathophysiology and risk factors of muscle and bone loss after SCI, including the mechanisms that may lead to muscle and bone loss after SCI. This review will also focus on current and future pharmacological and non-pharmacological therapies for reducing or eliminating neurogenic bone loss following SCI.
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spelling pubmed-105265162023-09-28 Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury Leone, Giovanna E. Shields, Donald C. Haque, Azizul Banik, Narendra L. Biomedicines Review Osteoporosis is a common skeletal disorder which can severely limit one’s ability to complete daily tasks due to the increased risk of bone fractures, reducing quality of life. Spinal cord injury (SCI) can also result in osteoporosis and sarcopenia. Most individuals experience sarcopenia and osteoporosis due to advancing age; however, individuals with SCI experience more rapid and debilitating levels of muscle and bone loss due to neurogenic factors, musculoskeletal disuse, and cellular/molecular events. Thus, preserving and maintaining bone mass after SCI is crucial to decreasing the risk of fragility and fracture in vulnerable SCI populations. Recent studies have provided an improved understanding of the pathophysiology and risk factors related to musculoskeletal loss after SCI. Pharmacological and non-pharmacological therapies have also provided for the reduction in or elimination of neurogenic bone loss after SCI. This review article will discuss the pathophysiology and risk factors of muscle and bone loss after SCI, including the mechanisms that may lead to muscle and bone loss after SCI. This review will also focus on current and future pharmacological and non-pharmacological therapies for reducing or eliminating neurogenic bone loss following SCI. MDPI 2023-09-20 /pmc/articles/PMC10526516/ /pubmed/37761022 http://dx.doi.org/10.3390/biomedicines11092581 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Leone, Giovanna E.
Shields, Donald C.
Haque, Azizul
Banik, Narendra L.
Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury
title Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury
title_full Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury
title_fullStr Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury
title_full_unstemmed Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury
title_short Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury
title_sort rehabilitation: neurogenic bone loss after spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526516/
https://www.ncbi.nlm.nih.gov/pubmed/37761022
http://dx.doi.org/10.3390/biomedicines11092581
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