Cargando…

Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults

To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:...

Descripción completa

Detalles Bibliográficos
Autores principales: Moriarty, Terence, Bourbeau, Kelsey, Dorman, Katie, Runyon, Lance, Glaser, Noah, Brandt, Jenna, Hoodjer, Mallory, Forbes, Scott C., Candow, Darren G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526554/
https://www.ncbi.nlm.nih.gov/pubmed/37759877
http://dx.doi.org/10.3390/brainsci13091276
_version_ 1785111046512443392
author Moriarty, Terence
Bourbeau, Kelsey
Dorman, Katie
Runyon, Lance
Glaser, Noah
Brandt, Jenna
Hoodjer, Mallory
Forbes, Scott C.
Candow, Darren G.
author_facet Moriarty, Terence
Bourbeau, Kelsey
Dorman, Katie
Runyon, Lance
Glaser, Noah
Brandt, Jenna
Hoodjer, Mallory
Forbes, Scott C.
Candow, Darren G.
author_sort Moriarty, Terence
collection PubMed
description To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:10 g/day or CR20:20 g/day) or a placebo (PLA:10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed, episodic memory, and attention) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O(2)Hb) during the cognitive evaluation. A two-way repeated measures ANOVA was used to determine the differences between the groups and the timepoints for the cognitive performance scores and PFC O(2)Hb. In addition, a one-way ANOVA of % change was used to determine pre- and post-differences between the groups. Creatine (independent of dosage) had no significant effect on the measures of cognitive performance. There was a trend for decreased relative PFC O(2)Hb in the CR10 group versus the PLA group in the processing speed test (p = 0.06). Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults.
format Online
Article
Text
id pubmed-10526554
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105265542023-09-28 Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults Moriarty, Terence Bourbeau, Kelsey Dorman, Katie Runyon, Lance Glaser, Noah Brandt, Jenna Hoodjer, Mallory Forbes, Scott C. Candow, Darren G. Brain Sci Article To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:10 g/day or CR20:20 g/day) or a placebo (PLA:10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed, episodic memory, and attention) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O(2)Hb) during the cognitive evaluation. A two-way repeated measures ANOVA was used to determine the differences between the groups and the timepoints for the cognitive performance scores and PFC O(2)Hb. In addition, a one-way ANOVA of % change was used to determine pre- and post-differences between the groups. Creatine (independent of dosage) had no significant effect on the measures of cognitive performance. There was a trend for decreased relative PFC O(2)Hb in the CR10 group versus the PLA group in the processing speed test (p = 0.06). Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults. MDPI 2023-09-01 /pmc/articles/PMC10526554/ /pubmed/37759877 http://dx.doi.org/10.3390/brainsci13091276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moriarty, Terence
Bourbeau, Kelsey
Dorman, Katie
Runyon, Lance
Glaser, Noah
Brandt, Jenna
Hoodjer, Mallory
Forbes, Scott C.
Candow, Darren G.
Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults
title Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults
title_full Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults
title_fullStr Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults
title_full_unstemmed Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults
title_short Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults
title_sort dose–response of creatine supplementation on cognitive function in healthy young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526554/
https://www.ncbi.nlm.nih.gov/pubmed/37759877
http://dx.doi.org/10.3390/brainsci13091276
work_keys_str_mv AT moriartyterence doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT bourbeaukelsey doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT dormankatie doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT runyonlance doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT glasernoah doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT brandtjenna doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT hoodjermallory doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT forbesscottc doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults
AT candowdarreng doseresponseofcreatinesupplementationoncognitivefunctioninhealthyyoungadults