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Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults
To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526554/ https://www.ncbi.nlm.nih.gov/pubmed/37759877 http://dx.doi.org/10.3390/brainsci13091276 |
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author | Moriarty, Terence Bourbeau, Kelsey Dorman, Katie Runyon, Lance Glaser, Noah Brandt, Jenna Hoodjer, Mallory Forbes, Scott C. Candow, Darren G. |
author_facet | Moriarty, Terence Bourbeau, Kelsey Dorman, Katie Runyon, Lance Glaser, Noah Brandt, Jenna Hoodjer, Mallory Forbes, Scott C. Candow, Darren G. |
author_sort | Moriarty, Terence |
collection | PubMed |
description | To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:10 g/day or CR20:20 g/day) or a placebo (PLA:10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed, episodic memory, and attention) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O(2)Hb) during the cognitive evaluation. A two-way repeated measures ANOVA was used to determine the differences between the groups and the timepoints for the cognitive performance scores and PFC O(2)Hb. In addition, a one-way ANOVA of % change was used to determine pre- and post-differences between the groups. Creatine (independent of dosage) had no significant effect on the measures of cognitive performance. There was a trend for decreased relative PFC O(2)Hb in the CR10 group versus the PLA group in the processing speed test (p = 0.06). Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults. |
format | Online Article Text |
id | pubmed-10526554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105265542023-09-28 Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults Moriarty, Terence Bourbeau, Kelsey Dorman, Katie Runyon, Lance Glaser, Noah Brandt, Jenna Hoodjer, Mallory Forbes, Scott C. Candow, Darren G. Brain Sci Article To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:10 g/day or CR20:20 g/day) or a placebo (PLA:10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed, episodic memory, and attention) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O(2)Hb) during the cognitive evaluation. A two-way repeated measures ANOVA was used to determine the differences between the groups and the timepoints for the cognitive performance scores and PFC O(2)Hb. In addition, a one-way ANOVA of % change was used to determine pre- and post-differences between the groups. Creatine (independent of dosage) had no significant effect on the measures of cognitive performance. There was a trend for decreased relative PFC O(2)Hb in the CR10 group versus the PLA group in the processing speed test (p = 0.06). Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults. MDPI 2023-09-01 /pmc/articles/PMC10526554/ /pubmed/37759877 http://dx.doi.org/10.3390/brainsci13091276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moriarty, Terence Bourbeau, Kelsey Dorman, Katie Runyon, Lance Glaser, Noah Brandt, Jenna Hoodjer, Mallory Forbes, Scott C. Candow, Darren G. Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults |
title | Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults |
title_full | Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults |
title_fullStr | Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults |
title_full_unstemmed | Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults |
title_short | Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults |
title_sort | dose–response of creatine supplementation on cognitive function in healthy young adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526554/ https://www.ncbi.nlm.nih.gov/pubmed/37759877 http://dx.doi.org/10.3390/brainsci13091276 |
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