Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4(+) T cells through regulating type 2 conventional dendritic cells

Rationale: An immunosuppressive tumor microenvironment (TME) is a major obstacle in tumor immunotherapy. Stimulator of interferon genes (STING) agonists trigger an inflammatory innate immune response to potentially overcome tumor immunosuppression. While STING agonists may hold promise as potential...

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Detalles Bibliográficos
Autores principales: Luo, Jing, Pang, Shuju, Hui, Zhenzhen, Zhao, Hua, Xu, Shilei, Yu, Wenwen, Yang, Lili, Sun, Qian, Hao, Xishan, Wei, Feng, Wang, Jian, Ren, Xiubao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526657/
https://www.ncbi.nlm.nih.gov/pubmed/37771774
http://dx.doi.org/10.7150/thno.86792

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