Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy

Background: Exploiting synthetic lethality (SL) relationships between protein pairs has emerged as an important avenue for the development of anti-cancer drugs. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of the NAD+ salvage pathway, having an SL relationship with nico...

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Detalles Bibliográficos
Autores principales: Kim, Minjee, Kim, Hyeyoung, Kang, Bu-Gyeong, Lee, Jooyoung, Kim, Taegun, Lee, Hwanho, Jung, Jane, Oh, Myung Joon, Seo, Seungyoon, Ryu, Myung-Jeom, Sung, Yeojin, Lee, Yunji, Yeom, Jeonghun, Han, Gyoonhee, Cha, Sun-Shin, Jung, Hosung, Kim, Hyun Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526665/
https://www.ncbi.nlm.nih.gov/pubmed/37771778
http://dx.doi.org/10.7150/thno.85356

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