Cargando…

Metyrapone Treatment Protects Low-Density Lipoprotein Receptor Knockout Mice against Hypercorticosteronemia Development without Changing Atherosclerosis Susceptibility

The steroid 11beta-hydroxylase inhibitor metyrapone is able to effectively reverse the hypercortisolemia detected in human Cushing’s Syndrome patients. In this current preclinical study, we investigated whether metyrapone monotherapy can also reverse the hypercortisolemia-associated increase in athe...

Descripción completa

Detalles Bibliográficos
Autores principales:	van der Sluis, Ronald J., van den Aardweg, Tim, Sijsenaar, Timothy J. P., Van Eck, Miranda, Hoekstra, Menno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526766/ https://www.ncbi.nlm.nih.gov/pubmed/37759687 http://dx.doi.org/10.3390/biom13091287

Ejemplares similares

Leukocytosis and Enhanced Susceptibility to Endotoxemia but Not Atherosclerosis in Adrenalectomized APOE Knockout Mice
por: Hoekstra, Menno, et al.
Publicado: (2013)

High-density lipoproteins and non-alcoholic fatty liver disease
por: Hoekstra, Menno, et al.
Publicado: (2023)

Bone Marrow Ts65Dn Trisomy-Induced Changes in Platelet Functionality and Lymphocytopenia Do Not Impact Atherosclerosis Susceptibility in Mice
por: Korporaal, Suzanne J. A., et al.
Publicado: (2021)

Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice
por: Hoekstra, Menno, et al.
Publicado: (2021)

PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice
por: de Jong, Laura M., et al.
Publicado: (2022)

PRMT5 inhibition induces pro‐inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice
por: Zhang, Yiheng, et al.
Publicado: (2023)

2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice
por: Snip, Olga S.C., et al.
Publicado: (2022)

Metyrapone: Various toxicities: case report
Publicado: (2021)

High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins
por: Hommes, Josefien W., et al.
Publicado: (2021)

Dietary-Induced Elevations of Triglyceride-Rich Lipoproteins Promote Atherosclerosis in the Low-Density Lipoprotein Receptor Knockout Syrian Golden Hamster
por: Lin, Xiao, et al.
Publicado: (2021)

Low-density lipoprotein particles in atherosclerosis
por: Qiao, Ya-Nan, et al.
Publicado: (2022)

Metyrapone for Long-Term Medical Management of Cushing's Syndrome
por: Traina, Andrea N., et al.
Publicado: (2013)

Cushing Disease Treated Successfully With Metyrapone During Pregnancy
por: Bass, Ilana Ramer, et al.
Publicado: (2021)

Adrenal Cushing Syndrome Diagnosed During Pregnancy: Successful Medical Management With Metyrapone
por: Azzola, Alescia, et al.
Publicado: (2020)

Primary prevention of atherosclerosis by pretreatment of low-density lipoprotein receptor knockout mice with sesame oil and its aqueous components
por: Aluganti Narasimhulu, Chandrakala, et al.
Publicado: (2018)

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells
por: Meng, Zhe, et al.
Publicado: (2019)

High density lipoproteins and atherosclerosis: emerging aspects
por: Sala, Federica, et al.
Publicado: (2012)

High density lipoprotein mimicking nanoparticles for atherosclerosis
por: Chen, Jun, et al.
Publicado: (2020)

Maternal Metyrapone Use During Breastfeeding: Safe for the Breastfed Infant
por: Duke, Madeline E, et al.
Publicado: (2019)

Long-term Treatment With Metyrapone in a Man With Ectopic Cushing Syndrome
por: Wong, Tin Wai
Publicado: (2022)

Oxidized low density lipoprotein, stem cells, and atherosclerosis
por: Yang, Hui, et al.
Publicado: (2012)

High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
por: Ossoli, Alice, et al.
Publicado: (2016)

Low-Density Lipoprotein Cholesterol, Structural Atherosclerosis, and Functional Atherosclerosis in Older Japanese
por: Shimizu, Yuji, et al.
Publicado: (2022)

Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE(-/-)/LDL(-/- )double knockout mice
por: Langheinrich, Alexander C, et al.
Publicado: (2010)

Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor‐driven transcription of hepatic lipogenic genes in vivo
por: Nahon, Joya E, et al.
Publicado: (2018)

Adrenal Cushing’s in Pregnancy, Managed with Metyrapone to Optimize for Adrenalectomy at 27 Weeks Gestation
por: Shah, Leena, et al.
Publicado: (2021)

Tumor Shrinkage by Metyrapone in Cushing Disease Exhibiting Glucocorticoid-Induced Positive Feedback
por: Tsujimoto, Yasutaka, et al.
Publicado: (2021)

Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency
por: Papierska, Lucyna, et al.
Publicado: (2022)

Probucol alleviates atherosclerosis and improves high density lipoprotein function
por: Zhong, Jian-Kai, et al.
Publicado: (2011)

The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts
por: Maiolino, Giuseppe, et al.
Publicado: (2013)

Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
por: Khatana, Chainika, et al.
Publicado: (2020)

MicroRNA-590 Inhibits Lipoprotein Lipase Expression and Prevents Atherosclerosis in apoE Knockout Mice
por: He, Ping-Ping, et al.
Publicado: (2015)

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis
por: Hermansson, Andreas, et al.
Publicado: (2010)

Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies
por: Duivenvoorden, Raphaël, et al.
Publicado: (2011)

Porphyromonas gingivalis accelerates atherosclerosis through oxidation of high-density lipoprotein
por: Kim, Hyun-Joo, et al.
Publicado: (2018)

Liver-Specific Commd1 Knockout Mice Are Susceptible to Hepatic Copper Accumulation
por: Vonk, Willianne I. M., et al.
Publicado: (2011)

The behavioral and neurochemical effects of methylprednisolone or metyrapone in a post-traumatic stress disorder rat model
por: Tanriverdi, Ayse Melek, et al.
Publicado: (2019)

Lipids and Lipoproteins in Atherosclerosis
por: Chroni, Angeliki, et al.
Publicado: (2011)

Lipids and Lipoproteins in Atherosclerosis
por: Bezsonov, Evgeny, et al.
Publicado: (2023)

On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_8goc3r2r2jobi0gttoi5j0sr3m