Cargando…
Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia
SIMPLE SUMMARY: In China, approximately 15,000 cases of childhood acute lymphoblastic leukemia (ALL) are diagnosed each year, and it is also the most common hematological cancer and the leading cause of tumor death under the age of 18. At present, ALL remains one of the major indications for allogen...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526786/ https://www.ncbi.nlm.nih.gov/pubmed/37760431 http://dx.doi.org/10.3390/cancers15184462 |
_version_ | 1785111065660489728 |
---|---|
author | Qiu, Kunyin Liao, Xiongyu Li, Yang Huang, Ke Xu, Honggui Fang, Jianpei Zhou, Dunhua |
author_facet | Qiu, Kunyin Liao, Xiongyu Li, Yang Huang, Ke Xu, Honggui Fang, Jianpei Zhou, Dunhua |
author_sort | Qiu, Kunyin |
collection | PubMed |
description | SIMPLE SUMMARY: In China, approximately 15,000 cases of childhood acute lymphoblastic leukemia (ALL) are diagnosed each year, and it is also the most common hematological cancer and the leading cause of tumor death under the age of 18. At present, ALL remains one of the major indications for allogeneic blood (ABT). This study aims to determine associations between ABT during the intensive induction phase of therapy and prognostic effect in a real-world cohort of pediatric patients with ALL. We found that among the blood products, only fresh frozen plasma (FFP) infusion is closely related to the prognosis of childhood ALL. During the intensive induction phase, the indications of FFP transfusion should be strictly grasped, and the total amount of FFP should be controlled and kept below 25 mL/kg. ABSTRACT: Purpose: To determine associations between allogeneic blood transfusion (ABT) during the intensive induction phase of therapy and prognostic effect in a real-world cohort of pediatric patients with acute lymphoblastic leukemia (ALL). Methods: A total of 749 pediatric patients who were diagnosed with ALL were enrolled in this study by using a single-center retrospective cohort study method from February 2008 to May 2022. Results: Among the ABT patients, 711 (94.9%) children were transfused with packed red blood cells (PRBCs), 434 (57.9%) with single-donor platelets (SDPs), and 196 (26.2%) with fresh frozen plasma (FFP). Our multivariate analysis demonstrated that FFP transfusion was the unique independent factor that affected both relapse-free survival (RFS) and overall survival (OS). The transfusion of FFP was significantly associated with higher age (p < 0.001), being more likely to receive SCCLG-ALL-2016 protocol (p < 0.001), higher proportion of more than 25 blood product transfusions, more PRBC transfusion (p < 0.001), and higher D33-MRD-positive rates (p = 0.013). Generalized additive models and threshold effect analysis using piece-wise linear regression were applied to identify the cut-off value of 25 mL/kg for average FFP transfusion. K-M survival analysis further confirmed that average FFP transfusion > 25 mL/kg was an independent adverse indicator of inferior outcome in terms of RFS (p = 0.027) and OS (p = 0.033). Conclusions: In blood products, only FFP supplement is closely related to the prognosis of childhood ALL. During the intensive induction phase, the indications of FFP transfusion should be strictly grasped, and the total amount of FFP should be controlled and kept below 25 mL/kg. |
format | Online Article Text |
id | pubmed-10526786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105267862023-09-28 Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia Qiu, Kunyin Liao, Xiongyu Li, Yang Huang, Ke Xu, Honggui Fang, Jianpei Zhou, Dunhua Cancers (Basel) Article SIMPLE SUMMARY: In China, approximately 15,000 cases of childhood acute lymphoblastic leukemia (ALL) are diagnosed each year, and it is also the most common hematological cancer and the leading cause of tumor death under the age of 18. At present, ALL remains one of the major indications for allogeneic blood (ABT). This study aims to determine associations between ABT during the intensive induction phase of therapy and prognostic effect in a real-world cohort of pediatric patients with ALL. We found that among the blood products, only fresh frozen plasma (FFP) infusion is closely related to the prognosis of childhood ALL. During the intensive induction phase, the indications of FFP transfusion should be strictly grasped, and the total amount of FFP should be controlled and kept below 25 mL/kg. ABSTRACT: Purpose: To determine associations between allogeneic blood transfusion (ABT) during the intensive induction phase of therapy and prognostic effect in a real-world cohort of pediatric patients with acute lymphoblastic leukemia (ALL). Methods: A total of 749 pediatric patients who were diagnosed with ALL were enrolled in this study by using a single-center retrospective cohort study method from February 2008 to May 2022. Results: Among the ABT patients, 711 (94.9%) children were transfused with packed red blood cells (PRBCs), 434 (57.9%) with single-donor platelets (SDPs), and 196 (26.2%) with fresh frozen plasma (FFP). Our multivariate analysis demonstrated that FFP transfusion was the unique independent factor that affected both relapse-free survival (RFS) and overall survival (OS). The transfusion of FFP was significantly associated with higher age (p < 0.001), being more likely to receive SCCLG-ALL-2016 protocol (p < 0.001), higher proportion of more than 25 blood product transfusions, more PRBC transfusion (p < 0.001), and higher D33-MRD-positive rates (p = 0.013). Generalized additive models and threshold effect analysis using piece-wise linear regression were applied to identify the cut-off value of 25 mL/kg for average FFP transfusion. K-M survival analysis further confirmed that average FFP transfusion > 25 mL/kg was an independent adverse indicator of inferior outcome in terms of RFS (p = 0.027) and OS (p = 0.033). Conclusions: In blood products, only FFP supplement is closely related to the prognosis of childhood ALL. During the intensive induction phase, the indications of FFP transfusion should be strictly grasped, and the total amount of FFP should be controlled and kept below 25 mL/kg. MDPI 2023-09-07 /pmc/articles/PMC10526786/ /pubmed/37760431 http://dx.doi.org/10.3390/cancers15184462 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Qiu, Kunyin Liao, Xiongyu Li, Yang Huang, Ke Xu, Honggui Fang, Jianpei Zhou, Dunhua Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia |
title | Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia |
title_full | Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia |
title_fullStr | Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia |
title_full_unstemmed | Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia |
title_short | Real-World Presentation and Prognostic Effect of Allogeneic Blood Transfusion during the Intensive Induction Phase in Pediatric Acute Lymphoblastic Leukemia |
title_sort | real-world presentation and prognostic effect of allogeneic blood transfusion during the intensive induction phase in pediatric acute lymphoblastic leukemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526786/ https://www.ncbi.nlm.nih.gov/pubmed/37760431 http://dx.doi.org/10.3390/cancers15184462 |
work_keys_str_mv | AT qiukunyin realworldpresentationandprognosticeffectofallogeneicbloodtransfusionduringtheintensiveinductionphaseinpediatricacutelymphoblasticleukemia AT liaoxiongyu realworldpresentationandprognosticeffectofallogeneicbloodtransfusionduringtheintensiveinductionphaseinpediatricacutelymphoblasticleukemia AT liyang realworldpresentationandprognosticeffectofallogeneicbloodtransfusionduringtheintensiveinductionphaseinpediatricacutelymphoblasticleukemia AT huangke realworldpresentationandprognosticeffectofallogeneicbloodtransfusionduringtheintensiveinductionphaseinpediatricacutelymphoblasticleukemia AT xuhonggui realworldpresentationandprognosticeffectofallogeneicbloodtransfusionduringtheintensiveinductionphaseinpediatricacutelymphoblasticleukemia AT fangjianpei realworldpresentationandprognosticeffectofallogeneicbloodtransfusionduringtheintensiveinductionphaseinpediatricacutelymphoblasticleukemia AT zhoudunhua realworldpresentationandprognosticeffectofallogeneicbloodtransfusionduringtheintensiveinductionphaseinpediatricacutelymphoblasticleukemia |