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Zebrafish as a Useful Model System for Human Liver Disease
Liver diseases represent a significant global health challenge, thereby necessitating extensive research to understand their intricate complexities and to develop effective treatments. In this context, zebrafish (Danio rerio) have emerged as a valuable model organism for studying various aspects of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526867/ https://www.ncbi.nlm.nih.gov/pubmed/37759472 http://dx.doi.org/10.3390/cells12182246 |
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author | Shimizu, Nobuyuki Shiraishi, Hiroshi Hanada, Toshikatsu |
author_facet | Shimizu, Nobuyuki Shiraishi, Hiroshi Hanada, Toshikatsu |
author_sort | Shimizu, Nobuyuki |
collection | PubMed |
description | Liver diseases represent a significant global health challenge, thereby necessitating extensive research to understand their intricate complexities and to develop effective treatments. In this context, zebrafish (Danio rerio) have emerged as a valuable model organism for studying various aspects of liver disease. The zebrafish liver has striking similarities to the human liver in terms of structure, function, and regenerative capacity. Researchers have successfully induced liver damage in zebrafish using chemical toxins, genetic manipulation, and other methods, thereby allowing the study of disease mechanisms and the progression of liver disease. Zebrafish embryos or larvae, with their transparency and rapid development, provide a unique opportunity for high-throughput drug screening and the identification of potential therapeutics. This review highlights how research on zebrafish has provided valuable insights into the pathological mechanisms of human liver disease. |
format | Online Article Text |
id | pubmed-10526867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105268672023-09-28 Zebrafish as a Useful Model System for Human Liver Disease Shimizu, Nobuyuki Shiraishi, Hiroshi Hanada, Toshikatsu Cells Review Liver diseases represent a significant global health challenge, thereby necessitating extensive research to understand their intricate complexities and to develop effective treatments. In this context, zebrafish (Danio rerio) have emerged as a valuable model organism for studying various aspects of liver disease. The zebrafish liver has striking similarities to the human liver in terms of structure, function, and regenerative capacity. Researchers have successfully induced liver damage in zebrafish using chemical toxins, genetic manipulation, and other methods, thereby allowing the study of disease mechanisms and the progression of liver disease. Zebrafish embryos or larvae, with their transparency and rapid development, provide a unique opportunity for high-throughput drug screening and the identification of potential therapeutics. This review highlights how research on zebrafish has provided valuable insights into the pathological mechanisms of human liver disease. MDPI 2023-09-11 /pmc/articles/PMC10526867/ /pubmed/37759472 http://dx.doi.org/10.3390/cells12182246 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shimizu, Nobuyuki Shiraishi, Hiroshi Hanada, Toshikatsu Zebrafish as a Useful Model System for Human Liver Disease |
title | Zebrafish as a Useful Model System for Human Liver Disease |
title_full | Zebrafish as a Useful Model System for Human Liver Disease |
title_fullStr | Zebrafish as a Useful Model System for Human Liver Disease |
title_full_unstemmed | Zebrafish as a Useful Model System for Human Liver Disease |
title_short | Zebrafish as a Useful Model System for Human Liver Disease |
title_sort | zebrafish as a useful model system for human liver disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526867/ https://www.ncbi.nlm.nih.gov/pubmed/37759472 http://dx.doi.org/10.3390/cells12182246 |
work_keys_str_mv | AT shimizunobuyuki zebrafishasausefulmodelsystemforhumanliverdisease AT shiraishihiroshi zebrafishasausefulmodelsystemforhumanliverdisease AT hanadatoshikatsu zebrafishasausefulmodelsystemforhumanliverdisease |