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Lipid Peroxidation and Antioxidant Protection
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins. The chemistry of LP and its biological consequences are reviewed with focus on th...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526874/ https://www.ncbi.nlm.nih.gov/pubmed/37759691 http://dx.doi.org/10.3390/biom13091291 |
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author | Valgimigli, Luca |
author_facet | Valgimigli, Luca |
author_sort | Valgimigli, Luca |
collection | PubMed |
description | Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins. The chemistry of LP and its biological consequences are reviewed with focus on the kinetics of the various processes, which helps understand the mechanisms and efficacy of antioxidant strategies. The main types of antioxidants are discussed in terms of structure–activity rationalization, with focus on mechanism and kinetics, as well as on their potential role in modulating ferroptosis. Phenols, pyri(mi)dinols, antioxidants based on heavy chalcogens (Se and Te), diarylamines, ascorbate and others are addressed, along with the latest unconventional antioxidant strategies based on the double-sided role of the superoxide/hydroperoxyl radical system. |
format | Online Article Text |
id | pubmed-10526874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105268742023-09-28 Lipid Peroxidation and Antioxidant Protection Valgimigli, Luca Biomolecules Review Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins. The chemistry of LP and its biological consequences are reviewed with focus on the kinetics of the various processes, which helps understand the mechanisms and efficacy of antioxidant strategies. The main types of antioxidants are discussed in terms of structure–activity rationalization, with focus on mechanism and kinetics, as well as on their potential role in modulating ferroptosis. Phenols, pyri(mi)dinols, antioxidants based on heavy chalcogens (Se and Te), diarylamines, ascorbate and others are addressed, along with the latest unconventional antioxidant strategies based on the double-sided role of the superoxide/hydroperoxyl radical system. MDPI 2023-08-24 /pmc/articles/PMC10526874/ /pubmed/37759691 http://dx.doi.org/10.3390/biom13091291 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Valgimigli, Luca Lipid Peroxidation and Antioxidant Protection |
title | Lipid Peroxidation and Antioxidant Protection |
title_full | Lipid Peroxidation and Antioxidant Protection |
title_fullStr | Lipid Peroxidation and Antioxidant Protection |
title_full_unstemmed | Lipid Peroxidation and Antioxidant Protection |
title_short | Lipid Peroxidation and Antioxidant Protection |
title_sort | lipid peroxidation and antioxidant protection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526874/ https://www.ncbi.nlm.nih.gov/pubmed/37759691 http://dx.doi.org/10.3390/biom13091291 |
work_keys_str_mv | AT valgimigliluca lipidperoxidationandantioxidantprotection |