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Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders

Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating c...

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Detalles Bibliográficos
Autores principales: Witkowska, Anna Maria, Salem, Joe-Elie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526920/
https://www.ncbi.nlm.nih.gov/pubmed/37759740
http://dx.doi.org/10.3390/biom13091340
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author Witkowska, Anna Maria
Salem, Joe-Elie
author_facet Witkowska, Anna Maria
Salem, Joe-Elie
author_sort Witkowska, Anna Maria
collection PubMed
description Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research.
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spelling pubmed-105269202023-09-28 Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders Witkowska, Anna Maria Salem, Joe-Elie Biomolecules Review Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research. MDPI 2023-09-02 /pmc/articles/PMC10526920/ /pubmed/37759740 http://dx.doi.org/10.3390/biom13091340 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Witkowska, Anna Maria
Salem, Joe-Elie
Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
title Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
title_full Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
title_fullStr Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
title_full_unstemmed Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
title_short Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
title_sort pharmacological and nutritional modulation of metabolome and metagenome in cardiometabolic disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526920/
https://www.ncbi.nlm.nih.gov/pubmed/37759740
http://dx.doi.org/10.3390/biom13091340
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