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Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating c...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526920/ https://www.ncbi.nlm.nih.gov/pubmed/37759740 http://dx.doi.org/10.3390/biom13091340 |
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author | Witkowska, Anna Maria Salem, Joe-Elie |
author_facet | Witkowska, Anna Maria Salem, Joe-Elie |
author_sort | Witkowska, Anna Maria |
collection | PubMed |
description | Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research. |
format | Online Article Text |
id | pubmed-10526920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105269202023-09-28 Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders Witkowska, Anna Maria Salem, Joe-Elie Biomolecules Review Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research. MDPI 2023-09-02 /pmc/articles/PMC10526920/ /pubmed/37759740 http://dx.doi.org/10.3390/biom13091340 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Witkowska, Anna Maria Salem, Joe-Elie Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
title | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
title_full | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
title_fullStr | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
title_full_unstemmed | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
title_short | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
title_sort | pharmacological and nutritional modulation of metabolome and metagenome in cardiometabolic disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526920/ https://www.ncbi.nlm.nih.gov/pubmed/37759740 http://dx.doi.org/10.3390/biom13091340 |
work_keys_str_mv | AT witkowskaannamaria pharmacologicalandnutritionalmodulationofmetabolomeandmetagenomeincardiometabolicdisorders AT salemjoeelie pharmacologicalandnutritionalmodulationofmetabolomeandmetagenomeincardiometabolicdisorders |