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SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease

Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on...

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Detalles Bibliográficos
Autores principales: Gao, Feng, Li, Fang, Wang, Jianhao, Yu, Hang, Li, Xiang, Chen, Hongyu, Wang, Jiabei, Qin, Dongdong, Li, Yiyi, Liu, Songyan, Zhang, Xi, Wang, Zhi-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526933/
https://www.ncbi.nlm.nih.gov/pubmed/37754114
http://dx.doi.org/10.3390/bios13090880
Descripción
Sumario:Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.