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SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease

Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on...

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Autores principales: Gao, Feng, Li, Fang, Wang, Jianhao, Yu, Hang, Li, Xiang, Chen, Hongyu, Wang, Jiabei, Qin, Dongdong, Li, Yiyi, Liu, Songyan, Zhang, Xi, Wang, Zhi-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526933/
https://www.ncbi.nlm.nih.gov/pubmed/37754114
http://dx.doi.org/10.3390/bios13090880
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author Gao, Feng
Li, Fang
Wang, Jianhao
Yu, Hang
Li, Xiang
Chen, Hongyu
Wang, Jiabei
Qin, Dongdong
Li, Yiyi
Liu, Songyan
Zhang, Xi
Wang, Zhi-Hao
author_facet Gao, Feng
Li, Fang
Wang, Jianhao
Yu, Hang
Li, Xiang
Chen, Hongyu
Wang, Jiabei
Qin, Dongdong
Li, Yiyi
Liu, Songyan
Zhang, Xi
Wang, Zhi-Hao
author_sort Gao, Feng
collection PubMed
description Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.
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spelling pubmed-105269332023-09-28 SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease Gao, Feng Li, Fang Wang, Jianhao Yu, Hang Li, Xiang Chen, Hongyu Wang, Jiabei Qin, Dongdong Li, Yiyi Liu, Songyan Zhang, Xi Wang, Zhi-Hao Biosensors (Basel) Review Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined. MDPI 2023-09-11 /pmc/articles/PMC10526933/ /pubmed/37754114 http://dx.doi.org/10.3390/bios13090880 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Feng
Li, Fang
Wang, Jianhao
Yu, Hang
Li, Xiang
Chen, Hongyu
Wang, Jiabei
Qin, Dongdong
Li, Yiyi
Liu, Songyan
Zhang, Xi
Wang, Zhi-Hao
SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
title SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
title_full SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
title_fullStr SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
title_full_unstemmed SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
title_short SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
title_sort sers-based optical nanobiosensors for the detection of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526933/
https://www.ncbi.nlm.nih.gov/pubmed/37754114
http://dx.doi.org/10.3390/bios13090880
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