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SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526933/ https://www.ncbi.nlm.nih.gov/pubmed/37754114 http://dx.doi.org/10.3390/bios13090880 |
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author | Gao, Feng Li, Fang Wang, Jianhao Yu, Hang Li, Xiang Chen, Hongyu Wang, Jiabei Qin, Dongdong Li, Yiyi Liu, Songyan Zhang, Xi Wang, Zhi-Hao |
author_facet | Gao, Feng Li, Fang Wang, Jianhao Yu, Hang Li, Xiang Chen, Hongyu Wang, Jiabei Qin, Dongdong Li, Yiyi Liu, Songyan Zhang, Xi Wang, Zhi-Hao |
author_sort | Gao, Feng |
collection | PubMed |
description | Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined. |
format | Online Article Text |
id | pubmed-10526933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105269332023-09-28 SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease Gao, Feng Li, Fang Wang, Jianhao Yu, Hang Li, Xiang Chen, Hongyu Wang, Jiabei Qin, Dongdong Li, Yiyi Liu, Songyan Zhang, Xi Wang, Zhi-Hao Biosensors (Basel) Review Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined. MDPI 2023-09-11 /pmc/articles/PMC10526933/ /pubmed/37754114 http://dx.doi.org/10.3390/bios13090880 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gao, Feng Li, Fang Wang, Jianhao Yu, Hang Li, Xiang Chen, Hongyu Wang, Jiabei Qin, Dongdong Li, Yiyi Liu, Songyan Zhang, Xi Wang, Zhi-Hao SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
title | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
title_full | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
title_fullStr | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
title_full_unstemmed | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
title_short | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
title_sort | sers-based optical nanobiosensors for the detection of alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526933/ https://www.ncbi.nlm.nih.gov/pubmed/37754114 http://dx.doi.org/10.3390/bios13090880 |
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