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Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis

Epidural administration is the leading therapeutic option for the management of pain associated with lumbar spinal stenosis (LSS), which is characterized by compression of the nerve root due to narrowing of the spinal canal. Corticosteroids are effective in alleviating LSS-related pain but can lead...

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Autores principales: Hong, Jin Young, Kim, Hyun, Yeo, Changhwan, Lee, Junseon, Jeon, Wan-Jin, Lee, Yoon Jae, Ha, In-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526993/
https://www.ncbi.nlm.nih.gov/pubmed/37759506
http://dx.doi.org/10.3390/cells12182281
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author Hong, Jin Young
Kim, Hyun
Yeo, Changhwan
Lee, Junseon
Jeon, Wan-Jin
Lee, Yoon Jae
Ha, In-Hyuk
author_facet Hong, Jin Young
Kim, Hyun
Yeo, Changhwan
Lee, Junseon
Jeon, Wan-Jin
Lee, Yoon Jae
Ha, In-Hyuk
author_sort Hong, Jin Young
collection PubMed
description Epidural administration is the leading therapeutic option for the management of pain associated with lumbar spinal stenosis (LSS), which is characterized by compression of the nerve root due to narrowing of the spinal canal. Corticosteroids are effective in alleviating LSS-related pain but can lead to complications with long-term use. Recent studies have focused on identifying promising medications administered epidurally to affected spinal regions. In this study, we aimed to investigate the effectiveness of harpagoside (HAS) as an epidural medication in rats with LSS. HAS at various concentrations was effective for neuroprotection against ferrous sulfate damage and consequent promotion of axonal outgrowth in primary spinal cord neurons. When two concentrations of HAS (100 and 200 μg/kg) were administered to the rat LSS model via the epidural space once a day for 4 weeks, the inflammatory responses around the silicone block used for LSS were substantially reduced. Consistently, pain-related factors were significantly suppressed by the epidural administration of HAS. The motor functions of rats with LSS significantly improved. These findings suggest that targeted delivery of HAS directly to the affected area via epidural injection holds promise as a potential treatment option for the recovery of patients with LSS.
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spelling pubmed-105269932023-09-28 Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis Hong, Jin Young Kim, Hyun Yeo, Changhwan Lee, Junseon Jeon, Wan-Jin Lee, Yoon Jae Ha, In-Hyuk Cells Article Epidural administration is the leading therapeutic option for the management of pain associated with lumbar spinal stenosis (LSS), which is characterized by compression of the nerve root due to narrowing of the spinal canal. Corticosteroids are effective in alleviating LSS-related pain but can lead to complications with long-term use. Recent studies have focused on identifying promising medications administered epidurally to affected spinal regions. In this study, we aimed to investigate the effectiveness of harpagoside (HAS) as an epidural medication in rats with LSS. HAS at various concentrations was effective for neuroprotection against ferrous sulfate damage and consequent promotion of axonal outgrowth in primary spinal cord neurons. When two concentrations of HAS (100 and 200 μg/kg) were administered to the rat LSS model via the epidural space once a day for 4 weeks, the inflammatory responses around the silicone block used for LSS were substantially reduced. Consistently, pain-related factors were significantly suppressed by the epidural administration of HAS. The motor functions of rats with LSS significantly improved. These findings suggest that targeted delivery of HAS directly to the affected area via epidural injection holds promise as a potential treatment option for the recovery of patients with LSS. MDPI 2023-09-15 /pmc/articles/PMC10526993/ /pubmed/37759506 http://dx.doi.org/10.3390/cells12182281 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hong, Jin Young
Kim, Hyun
Yeo, Changhwan
Lee, Junseon
Jeon, Wan-Jin
Lee, Yoon Jae
Ha, In-Hyuk
Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis
title Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis
title_full Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis
title_fullStr Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis
title_full_unstemmed Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis
title_short Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis
title_sort epidural injection of harpagoside for the recovery of rats with lumbar spinal stenosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526993/
https://www.ncbi.nlm.nih.gov/pubmed/37759506
http://dx.doi.org/10.3390/cells12182281
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